• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

实验性急性血源性骨髓炎中金黄色葡萄球菌黏附的超微结构研究

Ultrastructural studies of adherence of Staphylococcus aureus in experimental acute hematogenous osteomyelitis.

作者信息

Speers D J, Nade S M

出版信息

Infect Immun. 1985 Aug;49(2):443-6. doi: 10.1128/iai.49.2.443-446.1985.

DOI:10.1128/iai.49.2.443-446.1985
PMID:4018875
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC262038/
Abstract

A model of acute hematogenous osteomyelitis initiated by injection of Staphylococcus aureus into 29-day-old chickens was used. Transmission electron microscopy showed that the bacteria adhered to exposed cartilage matrix in the metaphyseal region of long bones but not to adjacent vascular linings or to erythrocytes. It is proposed that the combination of exposure of growth plate cartilage during normal bone growth and the ability of S. aureus to adhere to this cartilage is the mechanism for initiation of infection which proceeds to an osteomyelitic abscess.

摘要

采用向29日龄雏鸡注射金黄色葡萄球菌引发急性血源性骨髓炎的模型。透射电子显微镜显示，细菌粘附于长骨干骺端区域暴露的软骨基质，但不粘附于相邻的血管内衬或红细胞。有人提出，在正常骨骼生长过程中生长板软骨的暴露与金黄色葡萄球菌粘附于该软骨的能力相结合，是感染引发进而发展为骨髓炎脓肿的机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/a7146df9a65b/iai00113-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/7ceed166a73e/iai00113-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/678aec7a8d66/iai00113-0196-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/a7146df9a65b/iai00113-0197-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/7ceed166a73e/iai00113-0196-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/678aec7a8d66/iai00113-0196-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2d72/262038/a7146df9a65b/iai00113-0197-a.jpg

相似文献

1
Ultrastructural studies of adherence of Staphylococcus aureus in experimental acute hematogenous osteomyelitis.实验性急性血源性骨髓炎中金黄色葡萄球菌黏附的超微结构研究
Infect Immun. 1985 Aug;49(2):443-6. doi: 10.1128/iai.49.2.443-446.1985.
2
Acute haematogenous osteomyelitis and septic arthritis--a single disease. An hypothesis based upon the presence of transphyseal blood vessels.急性血源性骨髓炎和化脓性关节炎——一种单一疾病。基于骺板血管存在的假说。
J Bone Joint Surg Br. 1986 Mar;68(2):268-74. doi: 10.1302/0301-620X.68B2.3958014.
3
Acute hematogenous staphylococcal osteomyelitis. A description of the natural history in an avian model.急性血源性金黄色葡萄球菌骨髓炎。禽类模型中的自然病史描述。
Am J Pathol. 1983 Mar;110(3):333-45.
4
A novel mouse model of Staphylococcus aureus chronic osteomyelitis that closely mimics the human infection: an integrated view of disease pathogenesis.一种新型金黄色葡萄球菌慢性骨髓炎小鼠模型，可高度模拟人类感染：对发病机制的综合观察。
Am J Pathol. 2012 Oct;181(4):1206-14. doi: 10.1016/j.ajpath.2012.07.005. Epub 2012 Aug 16.
5
A non-traumatic Staphylococcus aureus osteomyelitis model in pigs.猪的非创伤性金黄色葡萄球菌骨髓炎模型。
In Vivo. 2010 May-Jun;24(3):257-64.
6
Acute hematogenous staphylococcal osteomyelitis: the effects of surgical drilling and curettage in an animal model.急性血源性金黄色葡萄球菌骨髓炎：手术钻孔和刮除术在动物模型中的效果
Pathology. 1986 Apr;18(2):227-33. doi: 10.3109/00313028609059464.
7
Distinct vasculotropic versus osteotropic features of S. agalactiae versus S. aureus implant-associated bone infection in mice.耐甲氧西林金黄色葡萄球菌与无乳链球菌致小鼠植入物相关骨感染的不同血管亲和性与成骨亲和性特征。
J Orthop Res. 2021 Feb;39(2):389-401. doi: 10.1002/jor.24962. Epub 2020 Dec 29.
8
Experimental acute hematogenous osteomyelitis in mice. I. Histopathological and immunological findings.小鼠实验性急性血源性骨髓炎。I. 组织病理学和免疫学研究结果。
J Orthop Res. 1999 May;17(3):376-81. doi: 10.1002/jor.1100170312.
9
Chronic Osteomyelitis with Staphylococcus aureus Deformation in Submicron Canaliculi of Osteocytes: A Case Report.慢性骨髓炎伴金黄色葡萄球菌在骨细胞亚微米小管中的变形：一例报告
JBJS Case Connect. 2018 Jan-Mar;8(1):e8. doi: 10.2106/JBJS.CC.17.00154.
10
Evidence of Staphylococcus Aureus Deformation, Proliferation, and Migration in Canaliculi of Live Cortical Bone in Murine Models of Osteomyelitis.金黄色葡萄球菌在小鼠骨髓炎模型中活皮质骨小管内的变形、增殖和迁移证据。
J Bone Miner Res. 2017 May;32(5):985-990. doi: 10.1002/jbmr.3055. Epub 2017 Jan 26.

引用本文的文献

1
Science-in-brief: Recent advances in failure of the blood supply to growth cartilage, osteochondrosis and developmental orthopaedic disease.简讯：生长软骨血液供应障碍、骨软骨病及发育性骨科疾病的最新进展
Equine Vet J. 2025 Sep;57(5):1161-1166. doi: 10.1111/evj.14486. Epub 2025 Feb 9.
2
Choosing the right animal model for osteomyelitis research: Considerations and challenges.选择合适的骨髓炎研究动物模型：考量因素与挑战。
J Orthop Translat. 2023 Nov 29;43:47-65. doi: 10.1016/j.jot.2023.10.001. eCollection 2023 Nov.
3
A Review on Pathophysiology, and Molecular Mechanisms of Bacterial Chondronecrosis and Osteomyelitis in Commercial Broilers.

本文引用的文献

1
Endochondral bone growth in the chick.鸡的软骨内骨生长。
AMA Arch Pathol. 1952 Jul;54(1):1-12.
2
Acute hematogenous staphylococcal osteomyelitis. A description of the natural history in an avian model.急性血源性金黄色葡萄球菌骨髓炎。禽类模型中的自然病史描述。
Am J Pathol. 1983 Mar;110(3):333-45.
3
Acute haematogenous osteomyelitis: an experimental model.急性血源性骨髓炎：一种实验模型。
商业肉鸡细菌性软骨坏死和骨髓炎的病理生理学及分子机制研究进展。
Biomolecules. 2023 Jun 23;13(7):1032. doi: 10.3390/biom13071032.
4
A method for labelling lesions for machine learning and some new observations on osteochondrosis in computed tomographic scans of four pig joints.一种用于机器学习的病变标记方法及对四只猪关节 CT 扫描中骨软骨病的一些新观察。
BMC Vet Res. 2022 Aug 31;18(1):328. doi: 10.1186/s12917-022-03426-x.
5
Osteochondrosis and other lesions in all intervertebral, articular process and rib joints from occiput to sacrum in pigs with poor back conformation, and relationship to juvenile kyphosis.猪的背形不良，从枕骨到荐骨的所有椎间、关节突和肋骨关节的骨软骨病和其他病变，以及与幼年脊柱前凸的关系。
BMC Vet Res. 2022 Jan 18;18(1):44. doi: 10.1186/s12917-021-03091-6.
6
Predilection for developing a hematogenous orthopaedic implant-associated infection in older versus younger mice.老年小鼠比年轻小鼠更容易发生血源性骨科植入物相关感染。
J Orthop Surg Res. 2021 Sep 14;16(1):556. doi: 10.1186/s13018-021-02594-0.
7
Acute Hematogenous Osteomyelitis in Children: Clinical Presentation and Management.儿童急性血源性骨髓炎：临床表现与治疗
Infect Drug Resist. 2020 Dec 14;13:4459-4473. doi: 10.2147/IDR.S257517. eCollection 2020.
8
Physeal bridges: causes, diagnosis, characterization and post-treatment imaging.骺板桥：病因、诊断、特征及治疗后影像学表现。
Pediatr Radiol. 2019 Nov;49(12):1595-1609. doi: 10.1007/s00247-019-04461-x. Epub 2019 Nov 4.
9
Prevalence of osteochondral lesions in the fetlock and hock joints of Standardbred horses that survived bacterial infection before 6 months of age.6月龄前曾患细菌感染且存活下来的标准赛马系马球关节和跗关节软骨下骨损伤的患病率。
BMC Vet Res. 2018 Dec 10;14(1):390. doi: 10.1186/s12917-018-1726-3.
10
Surgical Debridement Is Superior to Sole Antibiotic Therapy in a Novel Murine Posttraumatic Osteomyelitis Model.在一种新型小鼠创伤后骨髓炎模型中，手术清创术优于单纯抗生素治疗。
PLoS One. 2016 Feb 12;11(2):e0149389. doi: 10.1371/journal.pone.0149389. eCollection 2016.
J Pathol. 1983 Oct;141(2):157-67. doi: 10.1002/path.1711410206.
4
Effects of subinhibitory concentrations of antibiotics on Staphylococcus aureus interactions with fibronectin.亚抑菌浓度抗生素对金黄色葡萄球菌与纤连蛋白相互作用的影响。
J Antimicrob Chemother. 1983 Oct;12 Suppl C:85-95. doi: 10.1093/jac/12.suppl_c.85.
5
The fine structure of the proximal growth plate and metaphysis of the avian tibia: endochondral osteogenesis.鸟类胫骨近端生长板和干骺端的精细结构：软骨内成骨
J Anat. 1980 Jun;130(Pt 4):745-68.
6
Experimental osteomyelitis. I. A description of the model.实验性骨髓炎。I. 模型描述。
J Infect Dis. 1970 Nov;122(5):410-8. doi: 10.1093/infdis/122.5.410.
7
The development and morphology of the growth plates of two long bones of the turkey.
Res Vet Sci. 1973 Mar;14(2):161-6.
8
Acute hematogenous osteomyelitis: an experimental model.急性血源性骨髓炎：一种实验模型。
Surgery. 1976 Jan;79(1):97-9.
9
The fine structure of the proximal growth plate of the avian tibia.禽类胫骨近端生长板的精细结构。
J Anat. 1979 Mar;128(Pt 2):377-99.