Sun Xueheng, Xu Xiang, Yue Xiaokun, Wang Tianchang, Wang Zhaofei, Zhang Changru, Wang Jinwu
Department of Sport Rehabilitation, Shanghai University of Sport, Shanghai, 200438, China.
Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedic Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639 Zhizaoju Rd, Shanghai, 200011, China.
Adv Healthc Mater. 2024 Jan;13(1):e2301924. doi: 10.1002/adhm.202301924. Epub 2023 Sep 14.
With the discovery of the intrinsic enzyme-like activity of metal oxides, nanozymes garner significant attention due to their superior characteristics, such as low cost, high stability, multi-enzyme activity, and facile preparation. Notably, in the field of biomedicine, nanozymes primarily focus on disease detection, antibacterial properties, antitumor effects, and treatment of inflammatory conditions. However, the potential for application in regenerative medicine, which primarily addresses wound healing, nerve defect repair, bone regeneration, and cardiovascular disease treatment, is garnering interest as well. This review introduces nanozymes as an innovative strategy within the realm of bone regenerative medicine. The primary focus of this approach lies in the facilitation of osteochondral regeneration through the modulation of the pathological microenvironment. The catalytic mechanisms of four types of representative nanozymes are first discussed. The pathological microenvironment inhibiting osteochondral regeneration, followed by summarizing the therapy mechanism of nanozymes to osteochondral regeneration barriers is introduced. Further, the therapeutic potential of nanozymes for bone diseases is included. To improve the therapeutic efficiency of nanozymes and facilitate their clinical translation, future potential applications in osteochondral diseases are also discussed and some significant challenges addressed.
随着金属氧化物内在类酶活性的发现，纳米酶因其低成本、高稳定性、多酶活性和易于制备等优异特性而备受关注。值得注意的是，在生物医药领域，纳米酶主要集中于疾病检测、抗菌性能、抗肿瘤作用以及炎症病症的治疗。然而，其在再生医学领域（主要涉及伤口愈合、神经缺损修复、骨再生和心血管疾病治疗）的应用潜力也正在引起人们的兴趣。本综述将纳米酶作为骨再生医学领域的一种创新策略进行介绍。该方法的主要重点在于通过调节病理微环境来促进骨软骨再生。首先讨论了四种代表性纳米酶的催化机制。接着介绍了抑制骨软骨再生的病理微环境，随后总结了纳米酶对骨软骨再生障碍的治疗机制。此外，还包括纳米酶对骨疾病的治疗潜力。为了提高纳米酶的治疗效率并促进其临床转化，还讨论了其在骨软骨疾病未来的潜在应用，并解决了一些重大挑战。
