Davodabadi Fatemeh, Sajjadi Seyedeh Fatemeh, Sarhadi Mohammad, Mirghasemi Shaghayegh, Nadali Hezaveh Mahdieh, Khosravi Samin, Kamali Andani Mahdieh, Cordani Marco, Basiri Mohsen, Ghavami Saeid
Department of Biology, Faculty of Basic Science, Payame Noor University, Tehran, Iran.
School of Biological Science, Institute for Research in Fundamental Sciences (IPM), Tehran, Iran.
Eur J Pharmacol. 2023 Nov 5;958:176013. doi: 10.1016/j.ejphar.2023.176013. Epub 2023 Aug 24.
Conventional chemotherapy, one of the most widely used cancer treatment methods, has serious side effects, and usually results in cancer treatment failure. Drug resistance is one of the primary reasons for this failure. The most significant drawbacks of systemic chemotherapy are rapid clearance from the circulation, the drug's low concentration in the tumor site, and considerable adverse effects outside the tumor. Several ways have been developed to boost neoplasm treatment efficacy and overcome medication resistance. In recent years, targeted drug delivery has become an essential therapeutic application. As more mechanisms of tumor treatment resistance are discovered, nanoparticles (NPs) are designed to target these pathways. Therefore, understanding the limitations and challenges of this technology is critical for nanocarrier evaluation. Nano-drugs have been increasingly employed in medicine, incorporating therapeutic applications for more precise and effective tumor diagnosis, therapy, and targeting. Many benefits of NP-based drug delivery systems in cancer treatment have been proven, including good pharmacokinetics, tumor cell-specific targeting, decreased side effects, and lessened drug resistance. As more mechanisms of tumor treatment resistance are discovered, NPs are designed to target these pathways. At the moment, this innovative technology has the potential to bring fresh insights into cancer therapy. Therefore, understanding the limitations and challenges of this technology is critical for nanocarrier evaluation.
传统化疗是应用最广泛的癌症治疗方法之一，具有严重的副作用，且常导致癌症治疗失败。耐药性是导致治疗失败的主要原因之一。全身化疗最显著的缺点是药物在循环系统中迅速清除、在肿瘤部位的浓度较低以及在肿瘤外产生相当大的不良反应。人们已经开发了多种方法来提高肿瘤治疗效果并克服药物耐药性。近年来，靶向给药已成为一种重要的治疗应用。随着越来越多的肿瘤治疗耐药机制被发现，纳米颗粒（NPs）被设计用于靶向这些途径。因此，了解该技术的局限性和挑战对于纳米载体评估至关重要。纳米药物在医学中的应用越来越广泛，涵盖了更精确有效的肿瘤诊断、治疗和靶向的治疗应用。基于纳米颗粒的药物递送系统在癌症治疗中的诸多益处已得到证实，包括良好的药代动力学、肿瘤细胞特异性靶向、副作用减少和耐药性降低。随着越来越多的肿瘤治疗耐药机制被发现，纳米颗粒被设计用于靶向这些途径。目前，这项创新技术有可能为癌症治疗带来新的见解。因此，了解该技术的局限性和挑战对于纳米载体评估至关重要。
