Marine College, Shandong University, NO. 180 Wenhua West Road, Gao Strict, Weihai 264209, China.
Center for Nanomedicine, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Biomater Adv. 2023 Nov;154:213580. doi: 10.1016/j.bioadv.2023.213580. Epub 2023 Aug 6.
Marine polysaccharides (MPs) are exceptional bioactive materials that possess unique biochemical mechanisms and pharmacological stability, making them ideal for various tissue engineering applications. Certain MPs, including agarose, alginate, carrageenan, chitosan, and glucan have been successfully employed as biological scaffolds in animal studies. As carriers of signaling molecules, scaffolds can enhance the adhesion, growth, and differentiation of somatic cells, thereby significantly improving the tissue regeneration process. However, the biological benefits of pure MPs composite scaffold are limited. Therefore, physical, chemical, enzyme modification and other methods are employed to expand its efficacy. Chemically, the structural properties of MPs scaffolds can be altered through modifications to functional groups or molecular weight reduction, thereby enhancing their biological activities. Physically, MPs hydrogels and sponges emulate the natural extracellular matrix, creating a more conducive environment for tissue repair. The porosity and high permeability of MPs membranes and nanomaterials expedite wound healing. This review explores the distinctive properties and applications of select MPs in tissue regeneration, highlighting their structural versatility and biological applicability. Additionally, we provide a brief overview of common modification strategies employed for MP scaffolds. In conclusion, MPs have significant potential and are expected to be a novel regenerative material for tissue engineering.
海洋多糖（MPs）是具有独特生化机制和药理学稳定性的特殊生物活性物质，非常适合各种组织工程应用。某些 MPs，包括琼脂糖、藻酸盐、卡拉胶、壳聚糖和葡聚糖，已成功应用于动物研究中的生物支架。作为信号分子的载体，支架可以增强体细胞的黏附、生长和分化，从而显著改善组织再生过程。然而，纯 MPs 复合支架的生物学益处有限。因此，采用物理、化学、酶修饰等方法来扩大其功效。在化学方面，可以通过修饰功能基团或降低分子量来改变 MPs 支架的结构特性，从而增强其生物活性。在物理方面，MPs 水凝胶和海绵模仿天然细胞外基质，为组织修复创造更有利的环境。 MPs 膜和纳米材料的多孔性和高通透性加速了伤口愈合。本综述探讨了选定 MPs 在组织再生中的独特特性和应用，强调了它们结构的多功能性和生物适用性。此外，我们还简要介绍了 MPs 支架常用的改性策略。总之，MPs 具有重要的潜力，有望成为组织工程的新型再生材料。
