• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

刺激响应型透皮微针贴片

Stimuli-responsive transdermal microneedle patches.

作者信息

Makvandi Pooyan, Jamaledin Rezvan, Chen Guojun, Baghbantaraghdari Zahra, Zare Ehsan Nazarzadeh, Di Natale Concetta, Onesto Valentina, Vecchione Raffaele, Lee Jesse, Tay Franklin R, Netti Paolo, Mattoli Virgilio, Jaklenec Ana, Gu Zhen, Langer Robert

机构信息

Istituto Italiano di Tecnologia, Centre for Materials interfaces, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy.

Center for Advanced Biomaterials for Health Care (iit@CRIB), Istituto Italiano di Tecnologia, Naples, 80125, Italy.

出版信息

Mater Today (Kidlington). 2021 Jul-Aug;47:206-222. doi: 10.1016/j.mattod.2021.03.012. Epub 2021 May 20.

DOI:10.1016/j.mattod.2021.03.012
PMID:36338772
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9635273/
Abstract

Microneedle (MN) patches consisting of miniature needles have emerged as a promising tool to perforate the and translocate biomolecules into the dermis in a minimally invasive manner. Stimuli-responsive MN patches represent emerging drug delivery systems that release cargos on-demand as a response to internal or external triggers. In this review, a variety of stimuli-responsive MN patches for controlled drug release are introduced, covering the mechanisms of action toward different indications. Future opportunities and challenges with respect to clinical translation are also discussed.

摘要

由微型针头组成的微针贴片已成为一种很有前景的工具，能够以微创方式穿透皮肤并将生物分子转运至真皮层。刺激响应性微针贴片是新兴的药物递送系统，可根据内部或外部触发因素按需释放药物。在本综述中，介绍了多种用于控释药物的刺激响应性微针贴片，涵盖了针对不同适应症的作用机制。还讨论了临床转化方面的未来机遇和挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/c5c621aab89a/nihms-1801837-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/c47ea597510f/nihms-1801837-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/593930456012/nihms-1801837-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/7f19add32374/nihms-1801837-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/7822f5f9857f/nihms-1801837-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/f2596bb3f817/nihms-1801837-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/9fa5bb6cc6c2/nihms-1801837-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/995ab1c2a2ab/nihms-1801837-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/73eda2697327/nihms-1801837-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/538d53ea7809/nihms-1801837-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/b00dc69a4dfe/nihms-1801837-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/5d6009cb043c/nihms-1801837-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/39cade30f808/nihms-1801837-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/c5c621aab89a/nihms-1801837-f0013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/c47ea597510f/nihms-1801837-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/593930456012/nihms-1801837-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/7f19add32374/nihms-1801837-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/7822f5f9857f/nihms-1801837-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/f2596bb3f817/nihms-1801837-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/9fa5bb6cc6c2/nihms-1801837-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/995ab1c2a2ab/nihms-1801837-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/73eda2697327/nihms-1801837-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/538d53ea7809/nihms-1801837-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/b00dc69a4dfe/nihms-1801837-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/5d6009cb043c/nihms-1801837-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/39cade30f808/nihms-1801837-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e7b4/9635273/c5c621aab89a/nihms-1801837-f0013.jpg

相似文献

1
Stimuli-responsive transdermal microneedle patches.刺激响应型透皮微针贴片
Mater Today (Kidlington). 2021 Jul-Aug;47:206-222. doi: 10.1016/j.mattod.2021.03.012. Epub 2021 May 20.
2
Progress in Microneedle-Mediated Protein Delivery.微针介导蛋白质递送的研究进展
J Clin Med. 2020 Feb 17;9(2):542. doi: 10.3390/jcm9020542.
3
Microneedle-based insulin transdermal delivery system: current status and translation challenges.基于微针的胰岛素透皮给药系统：现状与转化挑战。
Drug Deliv Transl Res. 2022 Oct;12(10):2403-2427. doi: 10.1007/s13346-021-01077-3. Epub 2021 Oct 20.
4
Advances of microneedles in hormone delivery.微针在激素传递中的进展。
Biomed Pharmacother. 2022 Jan;145:112393. doi: 10.1016/j.biopha.2021.112393. Epub 2021 Nov 10.
5
Microneedle Patches-Integrated Transdermal Bioelectronics for Minimally Invasive Disease Theranostics.微针贴片集成经皮生物电子学用于微创疾病治疗诊断学。
Adv Healthc Mater. 2024 Jul;13(17):e2303921. doi: 10.1002/adhm.202303921. Epub 2024 Mar 17.
6
Stimuli-Responsive Microneedles as a Transdermal Drug Delivery System: A Demand-Supply Strategy.刺激响应型微针作为透皮给药系统：一种供需策略。
Biomacromolecules. 2022 Apr 11;23(4):1519-1544. doi: 10.1021/acs.biomac.1c01691. Epub 2022 Mar 11.
7
Innovative transdermal delivery of insulin using gelatin methacrylate-based microneedle patches in mice and mini-pigs.使用基于甲基丙烯酸明胶的微针贴片在小鼠和小型猪中进行胰岛素的创新透皮给药。
Nanoscale Horiz. 2022 Jan 31;7(2):174-184. doi: 10.1039/d1nh00596k.
8
Advances in Antimicrobial Microneedle Patches for Combating Infections.抗菌微针贴片在抗感染方面的进展。
Adv Mater. 2020 Aug;32(33):e2002129. doi: 10.1002/adma.202002129. Epub 2020 Jun 29.
9
Transdermal Insulin Delivery and Microneedles-based Minimally Invasive Delivery Systems.经皮胰岛素给药和基于微针的微创给药系统。
Curr Pharm Des. 2022;28(39):3175-3193. doi: 10.2174/1381612828666220608130056.
10
NIR-Remote Selectively Triggered Buprenorphine Hydrochloride Release from Microneedle Patches for the Treatment of Neuropathic Pain.近红外远程选择性触发微针贴剂释放盐酸丁丙诺啡用于治疗神经性疼痛
ACS Biomater Sci Eng. 2024 Aug 12;10(8):5001-5013. doi: 10.1021/acsbiomaterials.4c00733. Epub 2024 Jul 16.

引用本文的文献

1
Polymeric 3D-Printed Microneedle Arrays for Non-Transdermal Drug Delivery and Diagnostics.用于非透皮给药和诊断的聚合物3D打印微针阵列
Polymers (Basel). 2025 Jul 18;17(14):1982. doi: 10.3390/polym17141982.
2
Construction and applications of exosome-microneedle integrated systems.外泌体-微针集成系统的构建与应用
Int J Pharm X. 2025 Jul 15;10:100360. doi: 10.1016/j.ijpx.2025.100360. eCollection 2025 Dec.
3
Battery-free and self-propelled bionic microneedle system for chemically controlled on-demand drug delivery.用于化学控制按需给药的无电池自驱动仿生微针系统。

本文引用的文献

1
Immediate separation of microneedle tips from base array during skin insertion for instantaneous drug delivery.在皮肤插入过程中，微针尖端与基部阵列立即分离，以实现即时药物递送。
RSC Adv. 2018 May 15;8(32):17786-17796. doi: 10.1039/c8ra02334d. eCollection 2018 May 14.
2
Polymeric Microneedles Integrated with Metformin-Loaded and PDA/LA-Coated Hollow Mesoporous SiO for NIR-Triggered Transdermal Delivery on Diabetic Rats.整合有负载二甲双胍且涂覆有聚多巴胺/月桂酸的中空介孔二氧化硅的聚合物微针用于近红外触发的糖尿病大鼠经皮给药
ACS Appl Bio Mater. 2018 Dec 17;1(6):1906-1917. doi: 10.1021/acsabm.8b00470. Epub 2018 Dec 6.
3
Prevascularized Micro-/Nano-Sized Spheroid/Bead Aggregates for Vascular Tissue Engineering.
Microsyst Nanoeng. 2025 Jun 17;11(1):125. doi: 10.1038/s41378-025-00970-y.
4
Engineering microneedles for biosensing and drug delivery.用于生物传感和药物递送的工程微针。
Bioact Mater. 2025 Jun 1;52:36-59. doi: 10.1016/j.bioactmat.2025.05.027. eCollection 2025 Oct.
5
Advances in microneedle-based drug delivery system for metabolic diseases: structural considerations, design strategies, and future perspectives.用于代谢性疾病的基于微针的药物递送系统的进展：结构考量、设计策略及未来展望
J Nanobiotechnology. 2025 May 16;23(1):350. doi: 10.1186/s12951-025-03432-9.
6
Graphene-Based Polymeric Microneedles for Biomedical Applications: A Comprehensive Review.用于生物医学应用的基于石墨烯的聚合物微针：综述
ACS Appl Bio Mater. 2025 Mar 17;8(3):1835-1861. doi: 10.1021/acsabm.4c01884. Epub 2025 Feb 10.
7
Advances in the development of microarray patches in biomedicine.生物医学中微阵列贴片的发展进展。
N Biotechnol. 2025 May 25;86:25-30. doi: 10.1016/j.nbt.2025.01.003. Epub 2025 Jan 14.
8
Advancements in Materials for 3D-Printed Microneedle Arrays: Enhancing Performance and Biocompatibility.3D打印微针阵列材料的进展：提高性能和生物相容性
Micromachines (Basel). 2024 Nov 28;15(12):1433. doi: 10.3390/mi15121433.
9
Electrical Microneedles for Wound Treatment.用于伤口治疗的电微针
Adv Sci (Weinh). 2025 Jun;12(24):e2409519. doi: 10.1002/advs.202409519. Epub 2024 Nov 8.
10
Strategies for transportation of peptides across the skin for treatment of multiple diseases.肽经皮转运用于多种疾病治疗的策略。
Ther Deliv. 2025 Jan;16(1):63-86. doi: 10.1080/20415990.2024.2411943. Epub 2024 Oct 16.
用于血管组织工程的预血管化微/纳米级球体/微珠聚集体
Nanomicro Lett. 2021 Aug 18;13(1):182. doi: 10.1007/s40820-021-00697-1.
4
Separable Microneedles for Near-Infrared Light-Triggered Transdermal Delivery of Metformin in Diabetic Rats.用于近红外光触发二甲双胍经皮给药的可分离微针在糖尿病大鼠中的应用
ACS Biomater Sci Eng. 2018 Aug 13;4(8):2879-2888. doi: 10.1021/acsbiomaterials.8b00642. Epub 2018 Jul 6.
5
Developing Insulin Delivery Devices with Glucose Responsiveness.开发具有葡萄糖响应性的胰岛素输送装置。
Trends Pharmacol Sci. 2021 Jan;42(1):31-44. doi: 10.1016/j.tips.2020.11.002. Epub 2020 Nov 26.
6
Dual self-regulated delivery of insulin and glucagon by a hybrid patch.混合贴片的胰岛素和胰高血糖素双重自调节递送。
Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29512-29517. doi: 10.1073/pnas.2011099117. Epub 2020 Nov 11.
7
Advances in Antimicrobial Microneedle Patches for Combating Infections.抗菌微针贴片在抗感染方面的进展。
Adv Mater. 2020 Aug;32(33):e2002129. doi: 10.1002/adma.202002129. Epub 2020 Jun 29.
8
HO-Responsive mesoporous silica nanoparticles integrated with microneedle patches for the glucose-monitored transdermal delivery of insulin.与微针贴片集成的血红素加氧酶响应性介孔二氧化硅纳米颗粒用于胰岛素的葡萄糖监测透皮递送。
J Mater Chem B. 2017 Nov 7;5(41):8200-8208. doi: 10.1039/c7tb02082a. Epub 2017 Oct 9.
9
4D-Printed Dynamic Materials in Biomedical Applications: Chemistry, Challenges, and Their Future Perspectives in the Clinical Sector.4D 打印动态材料在生物医学中的应用：化学、挑战及其在临床领域的未来展望。
J Med Chem. 2020 Aug 13;63(15):8003-8024. doi: 10.1021/acs.jmedchem.9b02115. Epub 2020 Apr 17.
10
Facilitated Transdermal Drug Delivery Using Nanocarriers-Embedded Electroconductive Hydrogel Coupled with Reverse Electrodialysis-Driven Iontophoresis.使用嵌入纳米载体的导电水凝胶结合反向电渗析驱动离子导入实现促进透皮给药。
ACS Nano. 2020 Apr 28;14(4):4523-4535. doi: 10.1021/acsnano.0c00007. Epub 2020 Mar 24.