Ishak Azlan Iskandar, Kong Lai Shau, Yunus Mohd Razif Md, Bakar Mohd Zulkiflee Abu
Department of Otorhinolaryngology-Head and Neck Surgery, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia (UPM), 43400 Serdang, Selangor Malaysia.
Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 Serdang, Selangor Malaysia.
Indian J Otolaryngol Head Neck Surg. 2023 Sep;75(3):2577-2580. doi: 10.1007/s12070-023-03663-y. Epub 2023 May 2.
Lymphoepithelial carcinoma (LEC) is a rare entity of malignancy. It has been associated with Epstein-Barr virus (EBV), and in regions where it is endemic, such as Southeast Asia, EBV is typically associated with nasopharyngeal carcinoma. The incidence of such malignancies in the young population is unusual. Here we report a 17-year-old with a 5-year history of a painless right submandibular mass presenting with a sudden increase in size for one month before surgery. Neck examination revealed a firm right submandibular gland measuring five by five cm, with an irregular surface, non-tender with normal overlying skin. We performed a fine needle aspiration cytology (FNAC), and he underwent computed tomography (CT) scan of the neck. He underwent a right submandibulectomy. Lymph nodes from levels I and II were also removed. The final histopathology was reported as LEC. Following this tissue diagnosis, another follow-up surgery, a modified radical neck dissection, was carried out for locoregional clearance. Postoperatively, he completed chemoradiotherapy treatment and is now on regular follow-up.
淋巴上皮癌（LEC）是一种罕见的恶性肿瘤。它与爱泼斯坦-巴尔病毒（EBV）有关，在其地方流行区域，如东南亚，EBV通常与鼻咽癌相关。这类恶性肿瘤在年轻人群中的发病率并不常见。在此，我们报告一例17岁患者，其右侧颌下无痛性肿块已有5年病史，术前1个月肿块大小突然增大。颈部检查发现右侧颌下腺质地坚硬，大小为5×5厘米，表面不规则，无压痛，皮肤正常。我们进行了细针穿刺细胞学检查（FNAC），并对其颈部进行了计算机断层扫描（CT）。他接受了右侧颌下腺切除术。同时也切除了Ⅰ区和Ⅱ区的淋巴结。最终组织病理学报告为淋巴上皮癌。在做出该组织诊断后，又进行了一次后续手术，即改良根治性颈清扫术，以进行局部区域清除。术后，他完成了放化疗治疗，目前正在定期随访。
