State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Open Laboratory of Applied Microbiology, Guangdong Institute of Microbiology, Guangzhou 510070, China.
Program for Natural Products Chemical Biology, Key Laboratory of Plant Resources Conservation and Sustainable Utilization, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
Org Biomol Chem. 2020 Sep 30;18(37):7326-7329. doi: 10.1039/d0ob01674h.
Lithocaldehydes A (1) and B (2), a pair of novel diastereoisomers possessing an unprecedented 6/6/5/5/6 highly-fused ring system forming an earring-like skeleton, were isolated from the deep sea-derived fungus Phomopsis lithocarpus FS508. The structures of 1 and 2 were fully characterized and established through extensive spectroscopic interpretations and ECD calculations. Moreover, compounds 1 and 2 were shown to be promising antibiotics, exhibiting potent antifungal activities that are comparable to those of the positive control nystatin.
石炭醛 A（1）和 B（2）是一对新型非对映异构体，具有前所未有的 6/6/5/5/6 高度稠合环系，形成耳环状骨架，从深海来源的真菌 Phomopsis lithocarpus FS508 中分离得到。通过广泛的光谱解释和 ECD 计算，充分表征和确定了 1 和 2 的结构。此外，化合物 1 和 2 表现出有前景的抗生素活性，显示出与阳性对照制霉菌素相当的抗真菌活性。
