He Yuan, Yang Yuhang, Cheng Pengfei, Zhang Wei, Jia Jinghan, Ye Dawei, Wang Jinxi
Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Hepatobiliary Surgery, Baogang Hospital of InnerMongolia, Baotou 014000, China.
Mediators Inflamm. 2025 Jul 1;2025:4954551. doi: 10.1155/mi/4954551. eCollection 2025.
The aim of this study was to determine if there is an association between the dietary inflammatory index (DII) and nonalcoholic fatty liver disease (NAFLD). Study data were obtained from the National Health and Nutrition Examination Survey (NHANES) 2017-2018. Multiple logistic regression models were used to assess the association between DII and NAFLD. A restricted cubic spline (RCS) was used to investigate the non-linear association between DII and NAFLD. A total of 8708 people were included, with no age limit. In fully adjusted multiple regression models, DII < 0 was associated with fewer incident NAFLD events compared with DII ≥ 0. In the RCS model, there was a positive nonlinear relationship between DII and NAFLD. In addition, the main positive association between DII and NAFLD was found in participants aged ≥60 years and who were white females. A proinflammatory diet is associated with the development of NAFLD, and we recommend improving diet to reduce the risk of developing liver disease, especially NAFLD.
本研究的目的是确定饮食炎症指数（DII）与非酒精性脂肪性肝病（NAFLD）之间是否存在关联。研究数据来自2017 - 2018年国家健康与营养检查调查（NHANES）。使用多元逻辑回归模型评估DII与NAFLD之间的关联。采用受限立方样条（RCS）来研究DII与NAFLD之间的非线性关联。共纳入8708人，无年龄限制。在完全调整的多元回归模型中，与DII≥0相比，DII < 0与较少的新发NAFLD事件相关。在RCS模型中，DII与NAFLD之间存在正非线性关系。此外，DII与NAFLD之间的主要正相关在年龄≥60岁的参与者以及白人女性中被发现。促炎饮食与NAFLD的发生有关，我们建议改善饮食以降低患肝病尤其是NAFLD的风险。
