韩国奥密克戎（BA.1/BA.2）流行期间与 COVID-19 再感染和死亡相关的危险因素。
Risk Factors Related to COVID-19 Reinfection and Fatality During the Omicron (BA.1/BA.2) Period in Korea.
机构信息
Division of Epidemiological Investigation Analysis, Korea Disease Control and Prevention Agency, Cheongju, Korea.
Division of Infectious Disease Control, Korea Disease Control and Prevention Agency, Cheongju, Korea.
出版信息
J Korean Med Sci. 2023 Aug 28;38(34):e269. doi: 10.3346/jkms.2023.38.e269.
BACKGROUND
This study aimed to investigate the deaths due to coronavirus disease 2019 (COVID-19) reinfection and related risk factors.
METHODS
National cohort data were collected for a six-month period when omicron BA.1/BA.2 variant was dominant in South Korea.
RESULTS
The long-term care facility residents (adjusted odds ratio, 3.11; 95% confidence interval [CI], 2.98-3.25) had significantly higher risk of reinfection than the general population. The risk of reinfection was significantly lower for persons with 2 or more vaccine doses compared to the unvaccinated. The risk of death was significantly higher in the reinfection group than in the primary infection group for persons in the 60-74 years age group (adjusted relative risk [aRR], 1.62; 95% CI, 1.19-2.20), and immunocompromised group (aRR, 4.56; 95% CI, 2.34-8.90).
CONCLUSION
In these data, vaccination history was significantly related to reduced COVID-19 reinfection and severe progression, and scheduled vaccinations were important even with a history of infection.
背景
本研究旨在调查 2019 年冠状病毒病（COVID-19）再感染导致的死亡病例，并分析相关危险因素。
方法
在韩国奥密克戎 BA.1/BA.2 变异株占主导地位的六个月期间，收集了全国性队列数据。
结果
与普通人群相比，长期护理机构居民（调整后的优势比，3.11；95%置信区间[CI]，2.98-3.25）的再感染风险显著更高。与未接种疫苗者相比，接种 2 剂或更多疫苗者的再感染风险显著降低。对于 60-74 岁年龄组（调整后的相对风险[aRR]，1.62；95%CI，1.19-2.20）和免疫功能低下组（aRR，4.56；95%CI，2.34-8.90）的患者，再感染组的死亡风险显著高于初次感染组。
结论
在这些数据中，疫苗接种史与降低 COVID-19 再感染和严重病情进展显著相关，即使有感染史，定期接种疫苗也很重要。
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