Division of Epidemiological Investigation Analysis, Korea Disease Control and Prevention Agency, Cheongju, Korea.
Division of Infectious Disease Control, Korea Disease Control and Prevention Agency, Cheongju, Korea.
J Korean Med Sci. 2023 Aug 28;38(34):e269. doi: 10.3346/jkms.2023.38.e269.
This study aimed to investigate the deaths due to coronavirus disease 2019 (COVID-19) reinfection and related risk factors.
National cohort data were collected for a six-month period when omicron BA.1/BA.2 variant was dominant in South Korea.
The long-term care facility residents (adjusted odds ratio, 3.11; 95% confidence interval [CI], 2.98-3.25) had significantly higher risk of reinfection than the general population. The risk of reinfection was significantly lower for persons with 2 or more vaccine doses compared to the unvaccinated. The risk of death was significantly higher in the reinfection group than in the primary infection group for persons in the 60-74 years age group (adjusted relative risk [aRR], 1.62; 95% CI, 1.19-2.20), and immunocompromised group (aRR, 4.56; 95% CI, 2.34-8.90).
In these data, vaccination history was significantly related to reduced COVID-19 reinfection and severe progression, and scheduled vaccinations were important even with a history of infection.
本研究旨在调查 2019 年冠状病毒病（COVID-19）再感染导致的死亡病例，并分析相关危险因素。
在韩国奥密克戎 BA.1/BA.2 变异株占主导地位的六个月期间，收集了全国性队列数据。
与普通人群相比，长期护理机构居民（调整后的优势比，3.11；95%置信区间[CI]，2.98-3.25）的再感染风险显著更高。与未接种疫苗者相比，接种 2 剂或更多疫苗者的再感染风险显著降低。对于 60-74 岁年龄组（调整后的相对风险[aRR]，1.62；95%CI，1.19-2.20）和免疫功能低下组（aRR，4.56；95%CI，2.34-8.90）的患者，再感染组的死亡风险显著高于初次感染组。
在这些数据中，疫苗接种史与降低 COVID-19 再感染和严重病情进展显著相关，即使有感染史，定期接种疫苗也很重要。
