Department of Anesthesiology, Weifang Medical University, Weifang, Shandong Province, China.
Department of Anesthesiology, Zhucheng People's Hospital, No. 59 Nanhuan Road, Zhucheng, 262200, Shandong Province, China.
BMC Surg. 2024 Aug 24;24(1):240. doi: 10.1186/s12893-024-02527-8.
This study aimed to investigate the effects of combining remimazolam with estazolam on hemodynamics and pain levels after laparoscopic gastrointestinal surgery.
A total of 184 patients who underwent laparoscopic gastrointestinal surgery were enrolled in this double-blind randomized controlled trial. The patients were divided into four groups: Study Group 1(Remimazolam), Study Group 2(Estazolam), Study Group 3(Remimazolam + Estazolam), and Control Group. Anesthesia induction included intravenous injection of remimazolam and estazolam in the study groups, while the control group received normal saline. Hemodynamic parameters, stress responses, anxiety levels, and pain intensity were assessed at various time points.
The results showed that the combination of remimazolam and estazolam significantly improved hemodynamic parameters compared to the control group. Study Group 3 exhibited the lowest anxiety levels and stress responses among all groups. Furthermore, Study Group 3 had the lowest pain intensity scores at different postoperative time points.
The combination of remimazolam and estazolam effectively stabilized hemodynamics, reduced anxiety levels, and alleviated pain intensity after laparoscopic gastrointestinal surgery. These findings suggest that this combination therapy has the potential to improve surgical outcomes and patient comfort.
本研究旨在探讨雷米唑仑与依托咪酯联合用于腹腔镜胃肠手术后对血流动力学和疼痛程度的影响。
本双盲随机对照试验纳入了 184 例行腹腔镜胃肠手术的患者。患者被分为四组：研究组 1（雷米唑仑）、研究组 2（依托咪酯）、研究组 3（雷米唑仑+依托咪酯）和对照组。麻醉诱导包括在研究组中静脉注射雷米唑仑和依托咪酯，而对照组则给予生理盐水。在不同时间点评估血流动力学参数、应激反应、焦虑水平和疼痛强度。
结果表明，与对照组相比，雷米唑仑和依托咪酯联合使用显著改善了血流动力学参数。所有组中，研究组 3 的焦虑水平和应激反应最低。此外，研究组 3 在不同术后时间点的疼痛强度评分最低。
雷米唑仑和依托咪酯联合使用可有效稳定血流动力学，降低腹腔镜胃肠手术后的焦虑水平和疼痛强度。这些发现表明，这种联合治疗方法有可能改善手术结果和患者舒适度。
