Abinaya Kalaiselvan, Divya Rajsekaran, Asha Jeyakumar, Subha Anirudhan, Sneha Suresh Kumar, Adhityavasun Pazhamalai
Department of Conservative Dentistry and Endodontics, RVS Dental College and Hospital, Coimbatore, Tamil Nadu, India.
Consultant Endodontist, Bangalore, Karnataka, India.
J Pharm Bioallied Sci. 2023 Jul;15(Suppl 1):S760-S763. doi: 10.4103/jpbs.jpbs_39_23. Epub 2023 Jul 5.
The purpose of this study is to evaluate the Antimicrobial effect of liquorice extracts and compare its action to commonly used root canal medicaments like calcium hydroxide and chlorhexidine against and .
Ethanolic and aqueous extracts of liquorice root were prepared. Antimicrobial activity was tested by agar well diffusion method on and using Mueller Hinton agar. Wells were prepared and filled with ethanolic extract, aqueous extract of liquorice, calcium hydroxide, and chlorhexidine. Samples were incubated at 37°C, zone of inhibition was examined after 24 h.
Ethanolic extract was significantly better ( < 0.001) than calcium hydroxide and aqueous extract of liquorice and less effective than chlorhexidine against E.faecalis. In , ethanolic extract was less significant ( < 0.001) when compared to calcium hydroxide and chlorhexidine.
Ethanolic extract of liquorice has potent bactericidal effect against and over aqueous extract. Hence, it can be used as intracanal medicaments in routine endodontic therapy.
本研究旨在评估甘草提取物的抗菌作用，并将其作用与常用的根管药物如氢氧化钙和氯己定对粪肠球菌和变形链球菌的作用进行比较。
制备甘草根的乙醇提取物和水提取物。采用琼脂孔扩散法，以 Mueller Hinton 琼脂对粪肠球菌和变形链球菌进行抗菌活性测试。制备孔并分别填充乙醇提取物、甘草水提取物、氢氧化钙和氯己定。样品在 37°C 下孵育，24 小时后检查抑菌圈。
乙醇提取物对粪肠球菌的抗菌效果显著优于氢氧化钙和甘草水提取物（P < 0.001），但不如氯己定。在变形链球菌方面，与氢氧化钙和氯己定相比，乙醇提取物的抗菌效果不显著（P < 0.001）。
甘草乙醇提取物对粪肠球菌和变形链球菌的杀菌作用强于水提取物。因此，它可用于常规牙髓病治疗中的根管内药物。
