Cerro de las Campanas, Universidad Autónoma de Querétaro, Santiago de Querétaro, Qro, 76010, México.
Tecnológico Nacional de México/Instituto Tecnológico Superior de Ciudad Hidalgo, Av. Ing. Carlos Rojas Gutiérrez #2120, Ciudad Hidalgo, Michoacán, 61100, México.
Mol Cell Biochem. 2024 Aug;479(8):1985-1997. doi: 10.1007/s11010-023-04833-w. Epub 2023 Sep 1.
Quercetin is a flavonoid with promising therapeutic applications; nonetheless, the phenotype exerted in some diseases is contradictory. For instance, anticancer properties may be explained by a cytotoxic mechanism, whereas antioxidant-related neuroprotection is a pro-survival process. According to the available literature, quercetin exerts a redox interaction with the electron transport chain (ETC) in the mitochondrion, affecting its membrane potential. It also affects ATP generation by oxidative phosphorylation, where ATP deprivation could partly explain its cytotoxic effect. Moreover, quercetin may support the generation of free radicals through redox reactions, causing a prooxidant effect. The nutrimental stress and prooxidant effect induced by quercetin might promote pro-survival properties such as antioxidant processes. Thus, in this review, we discuss the evidence supporting that quercetin redox interaction with the ETC could explain its beneficial and toxic properties.
槲皮素是一种具有广阔治疗应用前景的类黄酮；然而，它在某些疾病中表现出的表型却是相互矛盾的。例如，抗癌特性可以用细胞毒性机制来解释，而与抗氧化相关的神经保护则是一种促进生存的过程。根据现有文献，槲皮素与线粒体电子传递链（ETC）发生氧化还原相互作用，影响其膜电位。它还会影响氧化磷酸化产生的 ATP，其中 ATP 的缺乏可能部分解释了其细胞毒性作用。此外，槲皮素可能通过氧化还原反应支持自由基的生成，从而产生促氧化剂效应。槲皮素引起的营养应激和促氧化剂效应可能促进抗氧化过程等促进生存的特性。因此，在本综述中，我们讨论了支持槲皮素与 ETC 的氧化还原相互作用可以解释其有益和毒性特性的证据。
