病毒劫持宿主表观遗传机制以损害免疫反应。
Virus hijacking of host epigenetic machinery to impair immune response.
作者信息
Locatelli Maëlle, Faure-Dupuy Suzanne
机构信息
Department of Biology, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina, USA.
Université de Paris Cité, Institut Cochin, Inserm U1016-CNRS UMR8104 , Paris, France.
出版信息
J Virol. 2023 Sep 28;97(9):e0065823. doi: 10.1128/jvi.00658-23. Epub 2023 Sep 1.
Abstract
Epigenetic modifications, such as DNA hypermethylation, histone acetylation/methylation, or nucleosome positioning, result in differential gene expression. These modifications can have an impact on various pathways, including host antiviral immune responses. In this review, we summarize the current understanding of epigenetic modifications induced by viruses to counteract host antiviral immune responses, which are crucial for establishing and maintaining infection of viruses. Finally, we provide insights into the potential use of epigenetic modulators in combating viral infections and virus-induced diseases.
摘要
表观遗传修饰，如DNA高甲基化、组蛋白乙酰化/甲基化或核小体定位，会导致基因表达差异。这些修饰可影响各种途径，包括宿主抗病毒免疫反应。在本综述中，我们总结了目前对病毒诱导的表观遗传修饰以对抗宿主抗病毒免疫反应的理解，这对于病毒的建立和维持感染至关重要。最后，我们深入探讨了表观遗传调节剂在对抗病毒感染和病毒诱导疾病方面的潜在用途。
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