GenOmics and Translational Research Center, RTI International, Research Triangle Park, 3040 East Cornwallis Road, Durham, NC, 27709-2194, USA.
Department of Epidemiology, Colorado School of Public Health, Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
Clin Epigenetics. 2023 Sep 2;15(1):142. doi: 10.1186/s13148-023-01552-3.
Epigenetic clocks are promising tools for assessing biological age. We assessed the accuracy of pediatric epigenetic clocks in gestational and chronological age determination.
Our study used data from seven tissue types on three DNA methylation profiling microarrays and found that the Knight and Bohlin clocks performed similarly for blood cells, while the Lee clock was superior for placental samples. The pediatric-buccal-epigenetic clock performed the best for pediatric buccal samples, while the Horvath clock is recommended for children's blood cell samples. The NeoAge clock stands out for its unique ability to predict post-menstrual age with high correlation with the observed age in infant buccal cell samples.
Our findings provide valuable guidance for future research and development of epigenetic clocks in pediatric samples, enabling more accurate assessments of biological age.
表观遗传钟是评估生物年龄的有前途的工具。我们评估了儿科表观遗传钟在确定胎龄和年龄方面的准确性。
我们的研究使用了三个 DNA 甲基化分析微阵列上七种组织类型的数据，发现 Knight 和 Bohlin 时钟在血细胞方面表现相似，而 Lee 时钟在胎盘样本方面表现更优。儿科-口腔-表观遗传时钟在儿科口腔样本方面表现最佳，而 Horvath 时钟则推荐用于儿童血细胞样本。NeoAge 时钟因其独特的预测月经后年龄的能力而脱颖而出，与婴儿口腔细胞样本中观察到的年龄高度相关。
我们的研究结果为儿科样本中表观遗传钟的未来研究和开发提供了有价值的指导，使生物年龄的评估更加准确。
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