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青年型帕金森病的诊断陷阱及其独特挑战:来自尼泊尔农村的病例报告

Diagnostic pitfalls in young onset parkinsonism and its unique challenges: A case report from rural Nepal.

作者信息

Bhattarai Himal Bikram, Basnet Bibhusan, Bhattarai Madhur, Shrestha Ayush, Gautam Swotantra, Lamichhane Saral, Uprety Manish, Pokhrel Bidushi, Sah Sanjit Kumar, Yadav Jayant

机构信息

Gandaki Medical College Teaching Hospital and Research Center Pvt Ltd, Pokhara, Nepal.

BP Koirala Institute of Health Sciences, Dharan, Nepal.

出版信息

SAGE Open Med Case Rep. 2023 Aug 30;11:2050313X231197062. doi: 10.1177/2050313X231197062. eCollection 2023.

DOI:10.1177/2050313X231197062
PMID:37663151
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10474787/
Abstract

Parkinson's disease is a neurodegenerative disease resulting from the loss of dopamine-secreting neurons present in the substantia nigra of the brain. Parkinson's disease is classified as early-onset and late-onset disease based on the time of its presentation. Since young patients with Parkinson's disease have an atypical clinical presentation and have to deal with their careers, raising families, or both at the time of diagnosis and also have a higher risk of drug-related side effects, it poses unique challenges for the patient, clinical team, and community. We present the case of a 40-year-old female with young onset Parkinson's disease from rural Nepal and the challenges faced during and after the disease in a resource-limited setting.

摘要

帕金森病是一种神经退行性疾病,由大脑黑质中分泌多巴胺的神经元丧失所致。根据发病时间,帕金森病可分为早发型和晚发型。由于年轻的帕金森病患者临床表现不典型,在诊断时还必须应对职业、抚养家庭或两者兼顾的问题,且药物相关副作用的风险更高,这给患者、临床团队和社区带来了独特的挑战。我们报告了一名来自尼泊尔农村的40岁早发型帕金森病女性患者的病例,以及在资源有限的环境中该疾病期间及之后所面临的挑战。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a33/10474787/62e3531db120/10.1177_2050313X231197062-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a33/10474787/62e3531db120/10.1177_2050313X231197062-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5a33/10474787/62e3531db120/10.1177_2050313X231197062-fig1.jpg

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Acta Neurobiol Exp (Wars). 2022;82(4):424-432. doi: 10.55782/ane-2022-040.
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Front Neurol. 2022 Nov 10;13:999820. doi: 10.3389/fneur.2022.999820. eCollection 2022.
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Young Onset Parkinson's Disease: A Modern and Tailored Approach.
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J Parkinsons Dis. 2020;10(s1):S29-S36. doi: 10.3233/JPD-202135.
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Pathogenetic insights into young-onset Parkinson disease.早发型帕金森病的发病机制洞察
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