Khan Mohd Mabood, Sharma Vineeta, Serajuddin Mohammad
Department of Zoology, University of Lucknow, Lucknow 226007, Uttar Pradesh, India.
Department of Medicine, Vanderbilt University Medical Center, Nashville 37232, TN, USA.
Gene. 2023 Dec 20;888:147761. doi: 10.1016/j.gene.2023.147761. Epub 2023 Sep 4.
Prostate cancer (PCa) is the most common cancer in men (20%) and is responsible for 6.8% (1/5) of all cancer-related deaths in men around the world. The development and spread of prostate cancer are driven by a wide variety of genomic changes and extensive epigenetic events. Because of this, the MicroRNA (miRNA) and associated molecular mechanisms involved in PCa genesis and aggressive were only partially identified until today. The miRNAs are a newly discovered category of regulatorsthat have recently been recognized to have a significant role in regulating numerous elements of cancer mechanisms, such as proliferation, differentiation, metabolism, and apoptosis. The miRNAs are a type of small (22-24 nucleotides), non-coding, endogenous, single-stranded RNA and work as potent gene regulators. Various types of cancer, including PCa, have found evidence that miRNA genes, which are often located in cancer-related genetic regions or fragile locations, have a role in the primary steps of tumorigenesis, either as oncogenes or tumorsuppressors. To explain the link between miRNAs and their function in the initiation and advancement of PCa, we conducted a preliminary assessment. The purpose of this research was to enhance our understanding of the connection between miRNA expression profiles and PCa by elucidating the fundamental processes of miRNA expression and the target genes.
前列腺癌（PCa）是男性中最常见的癌症（占20%），在全球男性所有癌症相关死亡中占6.8%（1/5）。前列腺癌的发展和扩散是由多种基因组变化和广泛的表观遗传事件驱动的。因此，直到如今，参与前列腺癌发生和侵袭的微小RNA（miRNA）及其相关分子机制仅得到部分识别。miRNA是一类新发现的调节因子，最近人们认识到它们在调节癌症机制的众多要素（如增殖、分化、代谢和凋亡）中发挥着重要作用。miRNA是一种小的（22 - 24个核苷酸）、非编码、内源性、单链RNA，作为有效的基因调节因子发挥作用。包括前列腺癌在内的各种癌症都已发现证据表明，miRNA基因通常位于与癌症相关的遗传区域或脆弱位点，在肿瘤发生的起始步骤中作为癌基因或肿瘤抑制基因发挥作用。为了解释miRNA与其在前列腺癌起始和进展中的功能之间的联系，我们进行了一项初步评估。本研究的目的是通过阐明miRNA表达的基本过程和靶基因，增进我们对miRNA表达谱与前列腺癌之间联系的理解。
