Center for Research on Population Health, National Institute of Public Health, Cuernavaca, Mexico.
Center for Research on Evaluation and Surveys, National Institute of Public Health, Cuernavaca, Mexico.
Int J Hyg Environ Health. 2023 Aug;253:114249. doi: 10.1016/j.ijheh.2023.114249. Epub 2023 Sep 5.
To estimate the frequency of detection and levels of aflatoxin B-lysine adduct (AFB-lys), an important hepatocellular carcinoma (HCC) risk factor, in eastern and southern Mexico.
We determined serum AFB-lys using mass spectrometry in a representative sample of 952 adults (weighted n = 7,493,354) from five states (Campeche, Chiapas, Tamaulipas, Veracruz and Yucatán) in 2018. We calculated overall and subgroup-specific frequency of detection and 95% confidence intervals (95%CI) and median AFB-lys levels and quartiles.
The overall frequency of detection of AFB-lys was 91.9% (95%CI 88.6, 94.3). The median AFB-lys level was 0.172 pg/μL (Q1-Q3, 0.060-0.582). Levels differed geographically (median pg/μL, 0.361 for Veracruz and 0.061 for Yucatan) and were higher among men and older individuals. Levels were almost three times higher in rural relative to urban areas (0.317 vs. 0.123 pg/μL). We observed higher AFB-lys exposure in lower socioeconomic status (SES) level populations.
AFB-lys frequency of detection was very high and exposure levels were highest in Veracruz, men, rural areas, and among persons of lower SES. Understanding modifiable HCC risk factors in populations with unique epidemiological patterns could inform preventative interventions.
估计在墨西哥东部和南部，作为肝细胞癌（HCC）重要风险因素之一的黄曲霉毒素 B-赖氨酸加合物（AFB-lys）的检出频率和水平。
我们使用质谱法在来自五个州（坎佩切、恰帕斯、塔毛利帕斯、韦拉克鲁斯和尤卡坦）的 952 名成年人（加权 n=7,493,354）的代表性样本中测定血清 AFB-lys。我们计算了总体和亚组特异性的检出频率和 95%置信区间（95%CI）以及中位数 AFB-lys 水平和四分位数。
AFB-lys 的总体检出频率为 91.9%（95%CI 88.6, 94.3）。AFB-lys 的中位数水平为 0.172pg/μL（Q1-Q3，0.060-0.582）。水平存在地域差异（中位数 pg/μL，Veracruz 为 0.361，尤卡坦为 0.061），男性和年龄较大的个体水平较高。农村地区的水平比城市地区高出近三倍（0.317 与 0.123pg/μL）。我们观察到较低社会经济地位（SES）水平人群的 AFB-lys 暴露量更高。
AFB-lys 的检出频率非常高，暴露水平在 Veracruz、男性、农村地区和 SES 较低的人群中最高。了解具有独特流行病学模式的人群中可改变的 HCC 风险因素可以为预防干预措施提供信息。
