de Landazuri M O, Silva A, Alvarez J, Herberman R B
J Immunol. 1979 Jul;123(1):252-8.
The present study strongly suggests that, in humans, natural killer (NK) activity and antibody-dependent cell-mediated cytotoxicity (ADCC) are mediated by the same effector cell population. This is supported by two different experimental approaches. First, competition for NK effector cells was accompanied by simultaneous inhibition of ADCC activity. Target cells sensitive to NK activity were capable of inhibiting specifically an ADCC assay in cold target competition experiments. Second, specific removal of NK cells on monolayers formed by target cells sensitive to NK activity caused simultaneous depletion of ADCC effector cells. In association with the removal on the monolayers of effector cells for ADCC as well as NK activity, we also found a significant depletion of cells bearing Fc gamma receptors.
本研究有力地表明，在人类中，自然杀伤（NK）活性和抗体依赖性细胞介导的细胞毒性（ADCC）由同一效应细胞群体介导。这得到了两种不同实验方法的支持。首先，对NK效应细胞的竞争伴随着ADCC活性的同时抑制。对NK活性敏感的靶细胞在冷靶竞争实验中能够特异性抑制ADCC检测。其次，对由对NK活性敏感的靶细胞形成的单层上的NK细胞进行特异性清除，会导致ADCC效应细胞同时耗竭。与单层上ADCC效应细胞以及NK活性效应细胞的清除相关联，我们还发现携带Fcγ受体的细胞显著减少。
