绿色超顺磁性氧化铁纳米颗粒作为利什曼病的一种新型高选择性治疗方法：针对细胞内无鞭毛体的体外研究
Green SPIONs as a novel highly selective treatment for leishmaniasis: an in vitro study against intracellular amastigotes.
作者信息
Verçoza Brunno Renato Farias, Bernardo Robson Roney, de Oliveira Luiz Augusto Sousa, Rodrigues Juliany Cola Fernandes
机构信息
Núcleo Multidisciplinar de Pesquisas em Biologia, NUMPEX-Bio, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil.
Núcleo Multidisciplinar de Pesquisas em Nanotecnologia, NUMPEX-Nano, Campus UFRJ Duque de Caxias Prof. Geraldo Cidade, Universidade Federal do Rio de Janeiro, Rodovia Washington Luiz, n. 19593, km 104.5, 25240-005, Duque de Caxias, RJ, Brasil.
出版信息
Beilstein J Nanotechnol. 2023 Aug 30;14:893-903. doi: 10.3762/bjnano.14.73. eCollection 2023.
The main goal of this work was to evaluate the therapeutic potential of green superparamagnetic iron oxide nanoparticles (SPIONs) produced with coconut water for treating cutaneous leishmaniasis caused by . Optical and electron microscopy techniques were used to evaluate the effects on cell proliferation, infectivity percentage, and ultrastructure. SPIONs were internalized by both parasite stages, randomly distributed in the cytosol and located mainly in membrane-bound compartments. The selectivity index for intracellular amastigotes was more than 240 times higher compared to current drugs used to treat the disease. The synthesized SPIONs showed promising activity against and can be considered a strong candidate for a new therapeutic approach for treating leishmaniases.
这项工作的主要目标是评估用椰子水制备的绿色超顺磁性氧化铁纳米颗粒（SPIONs）治疗由[病原体未明确]引起的皮肤利什曼病的治疗潜力。使用光学和电子显微镜技术来评估对细胞增殖、感染率和超微结构的影响。两个寄生虫阶段均摄取了SPIONs，它们随机分布在细胞质中，主要位于膜结合区室。与目前用于治疗该疾病的药物相比，细胞内无鞭毛体的选择性指数高出240倍以上。合成的SPIONs对[病原体未明确]显示出有前景的活性，可被视为治疗利什曼病新治疗方法的有力候选者。
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