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生物源四氧化三铁纳米颗粒的杀利什曼活性。

Leishmanicidal Activity of Biogenic Fe₃O₄ Nanoparticles.

作者信息

Khatami Mehrdad, Alijani Hajar, Sharifi Iraj, Sharifi Fatemeh, Pourseyedi Shahram, Kharazi Sam, Lima Nobre Marcos Augusto, Khatami Manouchehr

机构信息

School of Medicine, Bam University of Medical Sciences, Bam, Iran.

Nanomedicine and Nanobiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

出版信息

Sci Pharm. 2017 Nov 20;85(4):36. doi: 10.3390/scipharm85040036.

DOI:10.3390/scipharm85040036
PMID:29156612
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5748533/
Abstract

Due to the multiplicity of useful applications of metal oxide nanoparticles (ONPs) in medicine are growing exponentially, in this study, Fe₃O₄ (iron oxide) nanoparticles (IONPs) were biosynthesized using Rosemary to evaluate the leishmanicidal efficiency of green synthesized IONPs. This is the first report of the leishmanicidal efficiency of green synthesized IONPs against The resulting biosynthesized IONPs were characterized by ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD), transmission electron microscopy (TEM), and Fourier transform infrared spectroscopy (FTIR). The leishmanicidal activity of IONPS was studied via 3-4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. The results showed the fabrication of the spherical shape of monodisperse IONPs with a size 4 ± 2 nm. The UV-visible spectrophotometer absorption peak was at 334 nm. The leishmanicidal activity of biogenic iron oxide nanoparticles against (promastigote) was also studied. The IC of IONPs was 350 µg/mL. In this report, IONPs were synthesized via a green method. IONPs are mainly spherical and homogeneous, with an average size of about 4 nm, and were synthesized here using an eco-friendly, simple, and inexpensive method.

摘要

由于金属氧化物纳米颗粒（ONPs）在医学上的多种有用应用正呈指数级增长，在本研究中，使用迷迭香叶生物合成了Fe₃O₄（氧化铁）纳米颗粒（IONPs），以评估绿色合成的IONPs的杀利什曼原虫效率。这是关于绿色合成的IONPs对[具体对象缺失]的杀利什曼原虫效率的首次报道。通过紫外可见光谱（UV-Vis）、X射线衍射（XRD）、透射电子显微镜（TEM）和傅里叶变换红外光谱（FTIR）对所得生物合成的IONPs进行了表征。通过3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四氮唑溴盐（MTT）测定法研究了IONPs的杀利什曼原虫活性。结果表明制备出了尺寸为4±2nm的单分散球形IONPs。紫外可见分光光度计的吸收峰在334nm处。还研究了生物源氧化铁纳米颗粒对[具体对象缺失]（前鞭毛体）的杀利什曼原虫活性。IONPs的半数抑制浓度（IC）为350μg/mL。在本报告中，IONPs是通过绿色方法合成的。IONPs主要呈球形且均匀，平均尺寸约为4nm，并且在此采用了一种环保、简单且廉价的方法进行合成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/703d3c36ad21/scipharm-85-00036-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/82f83e10fb87/scipharm-85-00036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/0e1bbfdeb251/scipharm-85-00036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/7d28931d1630/scipharm-85-00036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/ec8d282d6f3c/scipharm-85-00036-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/703d3c36ad21/scipharm-85-00036-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/82f83e10fb87/scipharm-85-00036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/0e1bbfdeb251/scipharm-85-00036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/7d28931d1630/scipharm-85-00036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/ec8d282d6f3c/scipharm-85-00036-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ccff/5748533/703d3c36ad21/scipharm-85-00036-g005.jpg

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本文引用的文献

[1]
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Iran J Biotechnol. 2017-8-19

[2]
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IET Nanobiotechnol. 2017-4

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Food Chem. 2017-2-21

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Iran J Parasitol. 2016

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Sci Rep. 2016-9-1

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Iran J Basic Med Sci. 2016-2

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Sci Rep. 2016-4-13

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