Zimmerman M, Coryell W, Pfohl B
Arch Gen Psychiatry. 1986 Nov;43(11):1090-6. doi: 10.1001/archpsyc.1986.01800110076010.
We examined the psychosocial, demographic, and clinical correlates of familial subtypes of primary unipolar depression. Our findings supported the hypothesis that depression spectrum disease is a variant of neurotic depression, whereas familial pure depressive disease overlaps with endogenous depression. Patients with depressive spectrum disease experienced more life events, had more marital separations and divorces, had poorer social support, more frequently made a nonserious suicide attempt, and had a less characteristic endogenous symptom profile than patients with familial pure depressive disease. Consistent with our previous report on the relationship between dexamethasone suppression test results and familial subtyping, the broadness of the criteria used to diagnose the patients' first-degree relatives affected the strength of the association between the familial subtypes and the dependent variables.
我们研究了原发性单相抑郁症家族亚型的社会心理、人口统计学和临床相关因素。我们的研究结果支持了以下假设：抑郁谱系疾病是神经症性抑郁症的一种变体，而家族性单纯抑郁症与内源性抑郁症重叠。与家族性单纯抑郁症患者相比，抑郁谱系疾病患者经历了更多的生活事件，有更多的婚姻分居和离婚，社会支持较差，更频繁地进行非严重自杀未遂，且内源性症状特征不明显。与我们之前关于地塞米松抑制试验结果与家族亚型之间关系的报告一致，用于诊断患者一级亲属的标准宽泛程度影响了家族亚型与因变量之间关联的强度。
