Department of Chemical Engineering, Guangdong Technion-Israel Institute of Technology, 241 Daxue Road, Shantou, Guangdong 515063, China.
The Wolfson Department of Chemical Engineering, Technion-Israel Institute of Technology, Haifa 3200003, Israel.
ACS Nano. 2023 Sep 26;17(18):17634-17667. doi: 10.1021/acsnano.3c02513. Epub 2023 Sep 7.
Soft bioelectronics play an increasingly crucial role in high-precision therapeutics due to their softness, biocompatibility, clinical accuracy, long-term stability, and patient-friendliness. In this review, we provide a comprehensive overview of the latest representative therapeutic applications of advanced soft bioelectronics, ranging from wearable therapeutics for skin wounds, diabetes, ophthalmic diseases, muscle disorders, and other diseases to implantable therapeutics against complex diseases, such as cardiac arrhythmias, cancer, neurological diseases, and others. We also highlight key challenges and opportunities for future clinical translation and commercialization of soft therapeutic bioelectronics toward personalized medicine.
软生物电子学由于其柔软、生物相容性、临床准确性、长期稳定性和患者友好性，在高精度治疗中发挥着越来越重要的作用。在这篇综述中，我们全面概述了先进软生物电子学的最新代表性治疗应用，涵盖了从可穿戴治疗皮肤伤口、糖尿病、眼部疾病、肌肉疾病和其他疾病到针对复杂疾病（如心律失常、癌症、神经疾病等）的植入式治疗等多个方面。我们还强调了未来软治疗生物电子学向个性化医疗的临床转化和商业化所面临的关键挑战和机遇。
