Department of Maxillofacial Surgery, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.
Horm Metab Res. 2023 Sep;55(9):625-633. doi: 10.1055/a-2135-6659. Epub 2023 Sep 7.
Thyroid cancer is the most common malignant tumor of the endocrine system, and its incidence is increasing worldwide each year. This study aimed to explore the association between XRCC1, GSTM1, and GSTT1 polymorphisms in the model of thyroid cancer. The experiment was conducted by searching PubMed, Embase, and Web of Science, with the last search performed in March 2022. A total of 12 studies were included in this meta-analysis, with sample sizes ranging from 211 to 1124. The proportion of XRCC1 polymorphisms (rs25489, GG) in thyroid cancer was slightly lower than that of the normal control group, but the difference was not statistically significant (Mean difference=1.13, 95% CI: 0.99-1.28, p=0.08). The proportion of XRCC1 polymorphisms (rs25489, GA) in thyroid cancer was significantly lower than that of the normal control group (Mean difference=1.32, 95% CI: 1.16-1.52, p<0.00001). The proportion of XRCC1 polymorphisms (rs25489, AA) in thyroid cancer was slightly lower than that of the normal control group, but again, the difference was not statistically significant (Mean difference=0.78, 95% CI: 0.61-1.01, p=0.06). Similarly, the proportion of XRCC1 polymorphisms (rs25487, GG) and (rs25487, GA) in thyroid cancer was lower than that of the normal control group, but the differences were not statistically significant (p=0.22 and p=0.49, respectively). In conclusion, this study found that the proportion of XRCC1 polymorphisms (rs25489, AA) in thyroid cancer was lower than that of the normal control group.
甲状腺癌是内分泌系统最常见的恶性肿瘤，其发病率在全球范围内逐年上升。本研究旨在探讨 XRCC1、GSTM1 和 GSTT1 多态性与甲状腺癌模型的关系。实验通过检索 PubMed、Embase 和 Web of Science 进行，最后一次检索时间为 2022 年 3 月。共有 12 项研究纳入本荟萃分析，样本量范围为 211 至 1124。甲状腺癌中 XRCC1 多态性（rs25489，GG）的比例略低于正常对照组，但差异无统计学意义（均数差=1.13，95%置信区间：0.99-1.28，p=0.08）。甲状腺癌中 XRCC1 多态性（rs25489，GA）的比例明显低于正常对照组（均数差=1.32，95%置信区间：1.16-1.52，p<0.00001）。甲状腺癌中 XRCC1 多态性（rs25489，AA）的比例略低于正常对照组，但差异仍无统计学意义（均数差=0.78，95%置信区间：0.61-1.01，p=0.06）。同样，甲状腺癌中 XRCC1 多态性（rs25487，GG）和（rs25487，GA）的比例低于正常对照组，但差异无统计学意义（p=0.22 和 p=0.49）。综上所述，本研究发现甲状腺癌中 XRCC1 多态性（rs25489，AA）的比例低于正常对照组。
