Milley J R, Nugent S K, Rogers M C
J Pediatr. 1979 May;94(5):706-9. doi: 10.1016/s0022-3476(79)80134-1.
Three patients presenting with pulmonary edema associated with head trauma and increased intracranial pressure are described. Pulmonary edema is a clearly recognized complication of head trauma; the pathogenic mechanisms appear to be regulated by increased intracerebral pressure, sympathetically induced vascular hypertension, and increased pulmonary capillary permeability. If there is evidence that neurogenic pulmonary edema is the underlying etiology, therapeutic modalities should be directed at reducing intracranial pressure and strict attention paid to the interaction between intrathoracic and intracranial pressures in order to avoid the high mortality rate associated with this condition.
本文描述了3例因头部创伤和颅内压升高而出现肺水肿的患者。肺水肿是头部创伤一种公认的并发症；其发病机制似乎受颅内压升高、交感神经诱导的血管性高血压以及肺毛细血管通透性增加的调节。如果有证据表明神经源性肺水肿是潜在病因，治疗方式应旨在降低颅内压，并密切关注胸内压与颅内压之间的相互作用，以避免与该病症相关的高死亡率。
