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人口密集地区促进登革热媒介蚊虫的基因流动。

Dense residential areas promote gene flow in dengue vector mosquito .

作者信息

Yeo Huiqing, Tan Hui Zhen, Tang Qian, Tan Tyrone Ren Hao, Puniamoorthy Nalini, Rheindt Frank E

机构信息

Department of Biological Sciences, National University of Singapore, 16 Science Drive 4, Singapore 117558, Singapore.

出版信息

iScience. 2023 Aug 9;26(9):107577. doi: 10.1016/j.isci.2023.107577. eCollection 2023 Sep 15.

Abstract

is a successful disease vector due to its ability to survive in a wide range of habitats. Despite its ubiquity and impact on public health, little is known about its differential gene flow capabilities across different city habitats. We obtained a comprehensive dataset of >27,000 genome-wide DNA markers across 105 wild-caught individuals from Singapore, a dengue-endemic tropical city with heterogeneous landscapes from densely populated urban areas to forests. Despite Singapore's challenging small-scale heterogeneity, our landscape-genomic approach indicated that dense urban areas are characterized by higher gene flow rates than managed parks and forests. We documented the incidence of infections of involving two strains (AlbA and AlbB). Our results dispel the misconception that substantial dispersal of is limited to urban greenery, with wide implications for vector management and critical insights into urban planning strategies to combat dengue transmission.

摘要

由于其能够在广泛的栖息地中生存,它是一种成功的疾病传播媒介。尽管它无处不在且对公众健康有影响,但对于其在不同城市栖息地的差异基因流动能力却知之甚少。我们获得了一个全面的数据集,该数据集包含来自新加坡105个野生捕获个体的超过27000个全基因组DNA标记,新加坡是一个登革热流行的热带城市,其景观从人口密集的城市地区到森林各不相同。尽管新加坡存在具有挑战性的小规模异质性,但我们的景观基因组学方法表明,密集的城市地区比管理的公园和森林具有更高的基因流动率。我们记录了涉及两种菌株(AlbA和AlbB)的感染发生率。我们的结果消除了关于[传播媒介名称]的大量扩散仅限于城市绿化的误解,这对病媒管理具有广泛影响,并为对抗登革热传播的城市规划策略提供了关键见解。

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