Fathallah Sara, Abdellatif Ahmed, Saadeldin Mona Kamal
Biotechnology Program, School of Science and Engineering, American University in Cairo, New Cairo 11835, Egypt.
Biology Department, School of Science and Engineering, American University in Cairo, New Cairo 11835, Egypt.
Med Int (Lond). 2023 Aug 17;3(5):42. doi: 10.3892/mi.2023.102. eCollection 2023 Sep-Oct.
Driven by the limitations and obstacles of the available approaches and medications for multiple sclerosis (MS) that still cannot treat the disease, but only aid in accelerating the recovery from its attacks, the use of naturally occurring molecules as a potentially safe and effective treatment for MS is being explored in model organisms. MS is a devastating disease involving the brain and spinal cord, and its symptoms vary widely. Multiple molecular pathways are involved in the pathogenesis of the disease. The present review showcases the recent advancements in harnessing nature's resources to combat MS. By deciphering the molecular pathways involved in the pathogenesis of the disease, a wealth of potential therapeutic agents is uncovered that may revolutionize the treatment of MS. Thus, a new hope can be envisioned in the future, aiming at paving the way toward identifying novel safe alternatives to improve the lives of patients with MS.
由于目前用于治疗多发性硬化症（MS）的方法和药物存在局限性和障碍，这些方法和药物仍无法治愈该疾病，只能帮助加速从发作中恢复，因此正在模式生物中探索使用天然存在的分子作为MS的潜在安全有效治疗方法。MS是一种累及大脑和脊髓的毁灭性疾病，其症状差异很大。多种分子途径参与了该疾病的发病机制。本综述展示了利用自然资源对抗MS的最新进展。通过破译该疾病发病机制中涉及的分子途径，发现了大量潜在的治疗药物，这些药物可能会彻底改变MS的治疗方法。因此，可以展望未来有新的希望，旨在为确定新的安全替代方案铺平道路，以改善MS患者的生活。
