Canlıkarakaya Fırat, Ocaklı Serhat, Doğan İbrahim, Sucu Bedri Burak, Çınkıl Nurhak Cihangir
General Surgery, Amasya University Faculty of Medicine, Amasya, Türkiye.
General Surgery, Ankara Medipol University Faculty of Medicine, Ankara, Türkiye.
Biomark Med. 2025 Jun;19(12):463-469. doi: 10.1080/17520363.2025.2517534. Epub 2025 Jun 10.
Acute diverticulitis is an inflammatory process associated with pericolonic inflammation involving one or more colonic diverticula and is usually classified as uncomplicated or complicated.
This multicenter study retrospectively examined the data of 135 patients who received inpatient treatment for diverticulitis in two tertiary hospitals. Some inflammation scores were calculated with the data obtained from the patients' Complete blood count(CBC) and biochemical laboratory results, and the power of these scores in predicting complicated diverticulitis was examined.
A total of 135 patients (57 men and 78 women) were included in this study. In the ROC analysis performed to evaluate the effectiveness of predicting complications, the CRP/Albumin(CAR) score was found to be significant (AUC: 0.762, = 0.001). For a cutoff value > 0.25, CAR predicted complications with 73% sensitivity and 76% specificity (AUC: 0.762, = 0.001).
Determining the severity of the disease by differentiating complicated from uncomplicated cases will contribute to reducing hospital stay times and related costs. Our study showed that CAR score can be used as a reliable, inexpensive, and rapid marker for predicting complicated diverticulitis in acute diverticulitis.
急性憩室炎是一种与结肠周围炎症相关的炎症过程，涉及一个或多个结肠憩室，通常分为非复杂性或复杂性。
这项多中心研究回顾性分析了两家三级医院中135例接受憩室炎住院治疗患者的数据。利用患者全血细胞计数（CBC）和生化实验室结果所获数据计算了一些炎症评分，并检验了这些评分预测复杂性憩室炎的能力。
本研究共纳入135例患者（57例男性和78例女性）。在评估预测并发症有效性的ROC分析中，发现CRP/白蛋白（CAR）评分具有显著性（AUC：0.762，P = 0.001）。对于临界值>0.25，CAR预测并发症的灵敏度为73%，特异度为76%（AUC：0.762，P = 0.001）。
通过区分复杂性和非复杂性病例来确定疾病的严重程度，将有助于缩短住院时间和降低相关费用。我们的研究表明，CAR评分可作为预测急性憩室炎中复杂性憩室炎的可靠、廉价且快速的标志物。
