Department of Physiology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Cells. 2023 Aug 27;12(17):2154. doi: 10.3390/cells12172154.
COVID-19 had stormed through the world in early March of 2019, and on 5 May 2023, SARS-CoV-2 was officially declared to no longer be a global health emergency. The rise of new COVID-19 variants and , a product of recombinant variants and sub-strains, has fueled a need for continued surveillance of the pandemic as they have been deemed increasingly infectious. Regardless of the severity of the variant, this has caused an increase in hospitalizations, a strain in resources, and a rise of concern for public health. In addition, there is a growing population of patients experiencing cardiovascular complications as a result of post-acute sequelae of COVID-19. This review aims to focus on what was known about SARS-CoV-2 and its past variants (Alpha, Delta, Omicron) and how the knowledge has grown today with new emerging variants, with an emphasis on cardiovascular complexities. We focus on the possible mechanisms that cause the observations of chronic cardiac conditions seen even after patients have recovered from the infection. Further understanding of these mechanisms will help to close the gap in knowledge on post-acute sequelae of COVID-19 and the differences between the effects of variants.
2019 年 3 月，新冠疫情在全球范围内爆发，2023 年 5 月 5 日，世界卫生组织宣布新冠疫情不再构成“国际关注的突发公共卫生事件”。新的新冠病毒变种的出现，如重组变种和亚系，被认为具有更强的传染性，这使得我们需要继续对疫情进行监测。无论变异株的严重程度如何，这都导致了住院人数的增加、资源紧张以及对公众健康的担忧增加。此外，越来越多的患者因新冠病毒感染的急性后遗症而出现心血管并发症。本综述旨在重点关注已知的关于 SARS-CoV-2 及其过去的变种（Alpha、Delta、Omicron）的信息，以及随着新出现的变种，这些知识是如何增长的，重点是心血管并发症的复杂性。我们关注的是导致即使患者从感染中康复后仍出现慢性心脏疾病的观察结果的可能机制。进一步了解这些机制将有助于缩小新冠病毒感染急性后遗症的知识差距，并了解不同变种的影响。
