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肠刷状缘膜中根皮苷敏感糖载体介导的D-葡萄糖氢离子偶联转运。

Hydrogen ion-coupled transport of D-glucose by phlorizin-sensitive sugar carrier in intestinal brush-border membranes.

作者信息

Hoshi T, Takuwa N, Abe M, Tajima A

出版信息

Biochim Biophys Acta. 1986 Oct 23;861(3):483-8. doi: 10.1016/0005-2736(86)90458-x.

DOI:10.1016/0005-2736(86)90458-x
PMID:3768358
Abstract

In rabbit intestinal brush-border membrane vesicles, Na+-independent D-glucose uptake in the presence of an inside-negative transmembrane potential was found to be stimulated by an imposed pH gradient. Na+-independent, pH-dependent and phlorizin-sensitive D-glucose-evoked potentials could be recorded from isolated toad intestine. The obtained data suggest that phlorizin-sensitive D-glucose carriers of intestinal brush-border membrane can interact with H+ when Na+ is absent.

摘要

在兔肠刷状缘膜囊泡中,发现在存在内向负跨膜电位的情况下,施加的pH梯度可刺激非Na⁺依赖性D - 葡萄糖摄取。从离体蟾蜍肠可记录到非Na⁺依赖性、pH依赖性且对根皮苷敏感的D - 葡萄糖诱发电位。所获数据表明,当不存在Na⁺时,肠刷状缘膜的根皮苷敏感D - 葡萄糖载体可与H⁺相互作用。

相似文献

1
Hydrogen ion-coupled transport of D-glucose by phlorizin-sensitive sugar carrier in intestinal brush-border membranes.肠刷状缘膜中根皮苷敏感糖载体介导的D-葡萄糖氢离子偶联转运。
Biochim Biophys Acta. 1986 Oct 23;861(3):483-8. doi: 10.1016/0005-2736(86)90458-x.
2
4-Azidophlorizin, a high affinity probe and photoaffinity label for the glucose transporter in brush border membranes.4-叠氮根根皮苷,一种用于刷状缘膜中葡萄糖转运蛋白的高亲和力探针和光亲和标记物。
Biochim Biophys Acta. 1982 Jun 14;688(2):547-56. doi: 10.1016/0005-2736(82)90366-2.
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Similarity in effects of Na+ gradients and membrane potentials on D-glucose transport by, and phlorizin binding to, vesicles derived from brush borders of rattit intestinal mucosal cells.钠离子梯度和膜电位对源自大鼠小肠黏膜细胞刷状缘的囊泡摄取D-葡萄糖及根皮素结合的影响的相似性。
J Membr Biol. 1978 May 3;40(3):269-90. doi: 10.1007/BF02002972.
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Effect of phloretin on Na+-dependent D-glucose uptake by intestinal brush border membrane vesicles.根皮素对肠刷状缘膜囊泡钠依赖性葡萄糖摄取的影响。
Biochem Pharmacol. 1983 Nov 15;32(22):3453-7. doi: 10.1016/0006-2952(83)90376-3.
5
Phlorizin as a probe of the small-intestinal Na+,D-glucose cotransporter. A model.根皮苷作为小肠钠-葡萄糖共转运体的探针。一个模型。
Biochim Biophys Acta. 1982 Jun 14;688(2):557-71. doi: 10.1016/0005-2736(82)90367-4.
6
Potential-dependent D-glucose uptake by renal brush border membrane vesicles in the absence of sodium.在无钠情况下肾刷状缘膜囊泡对葡萄糖的电位依赖性摄取。
Am J Physiol. 1982 Apr;242(4):F340-5. doi: 10.1152/ajprenal.1982.242.4.F340.
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1,25-Dihydroxycholecalciferol-related Na+/D-glucose transport in brush-border membrane vesicles from embryonic chick jejunum. Modulation by triiodothyronine.
Eur J Biochem. 1991 Nov 1;201(3):709-13. doi: 10.1111/j.1432-1033.1991.tb16332.x.
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The Na+ gradient-dependent transport of D-glucose in renal brush border membranes.肾刷状缘膜中D-葡萄糖的钠梯度依赖性转运。
J Biol Chem. 1975 Aug 10;250(15):6032-9.
9
Structural state of the Na+/D-glucose cotransporter in calf kidney brush-border membranes. Target size analysis of Na+-dependent phlorizin binding and Na+-dependent D-glucose transport.小牛肾刷状缘膜中钠/葡萄糖协同转运蛋白的结构状态。对钠依赖性根皮苷结合和钠依赖性葡萄糖转运的靶标大小分析。
Biochim Biophys Acta. 1984 Nov 7;777(2):201-8. doi: 10.1016/0005-2736(84)90421-8.
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Differences in neutral amino acid and glucose transport between brush border and basolateral plasma membrane of intestinal epithelial cells.肠道上皮细胞刷状缘和基底外侧质膜之间中性氨基酸和葡萄糖转运的差异。
J Cell Physiol. 1976 Dec;89(4):805-10. doi: 10.1002/jcp.1040890447.

引用本文的文献

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H+-coupled nutrient, micronutrient and drug transporters in the mammalian small intestine.哺乳动物小肠中的H⁺偶联营养物质、微量营养素和药物转运体。
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H(+)/solute-induced intracellular acidification leads to selective activation of apical Na(+)/H(+) exchange in human intestinal epithelial cells.
氢离子/溶质诱导的细胞内酸化导致人肠上皮细胞顶端钠/氢交换的选择性激活。
J Clin Invest. 1999 Sep;104(5):629-35. doi: 10.1172/JCI7192.
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Characteristics of transmural potential changes associated with the proton-peptide co-transport in toad small intestine.蟾蜍小肠中质子 - 肽共转运相关的跨壁电位变化特征。
J Physiol. 1987 Dec;394:481-99. doi: 10.1113/jphysiol.1987.sp016882.
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A proton gradient, not a sodium gradient, is the driving force for active transport of lactate in rabbit intestinal brush-border membrane vesicles.质子梯度而非钠梯度是家兔小肠刷状缘膜囊泡中乳酸主动转运的驱动力。
Biochem J. 1988 Nov 15;256(1):219-23. doi: 10.1042/bj2560219.