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[大鼠肝脏中脂质氧化产物的稳定性及其利用途径]

[Stability of lipid oxidation products in the rat liver and pathways of their utilization].

作者信息

Kostiuk V A

出版信息

Biokhimiia. 1986 Aug;51(8):1392-7.

PMID:3768441
Abstract

The ability of liver homogenates to utilize various lipid peroxidation products was studied. Conjugated dienes and TBA-reactive products of unsaturated fatty acid phospholipids and triglycerides were found to be more stable that the corresponding lipid hydroperoxides. It was shown that decomposition of lipid hydroperoxides in liver homogenates is due to their reduction to corresponding oxycompounds without activation of free radical reactions. The ability of lipid hydroperoxides to be reduced in liver homogenates is determined by their chemical structure and decreases in the following order: polyunsaturated fatty acids--phospholipids--triglycerides--cholesterol esters.

摘要

研究了肝脏匀浆利用各种脂质过氧化产物的能力。发现共轭二烯以及不饱和脂肪酸磷脂和甘油三酯的TBA反应产物比相应的脂质氢过氧化物更稳定。结果表明,肝脏匀浆中脂质氢过氧化物的分解是由于它们还原为相应的含氧化合物,而未激活自由基反应。脂质氢过氧化物在肝脏匀浆中被还原的能力取决于其化学结构,按以下顺序降低:多不饱和脂肪酸——磷脂——甘油三酯——胆固醇酯。

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