Department of Rehabilitation Sciences and Health Technology, Oslo Metropolitan University, Oslo, Norway.
Orthopedic department, Akershus University Hospital, Lørenskog, Norway.
BMC Musculoskelet Disord. 2023 Sep 8;24(1):714. doi: 10.1186/s12891-023-06831-x.
To evaluate the efficacy of strength exercise or aerobic exercise compared to usual care on knee-related quality of life (QoL) and knee function at 4 months and 1 year in individuals with knee osteoarthritis.
A three-arm randomized controlled trial (RCT) compared 12 weeks of strength exercise or aerobic exercise (stationary cycling) to usual care supervised by physiotherapists in primary care. We recruited 168 participants aged 35-70 years with symptomatic knee osteoarthritis. The primary outcome was The Knee Injury and Osteoarthritis Outcome Score (KOOS) QoL at 1 year. Secondary outcomes were self-reported function, pain, and self-efficacy, muscle strength and maximal oxygen uptake (VO) at 4 months and 1 year.
There were no differences between strength exercise and usual care on KOOS QoL (6.5, 95% CI -0.9 to 14), or for aerobic exercise and usual care (5.0, 95% CI -2.7 to 12.8), at 1 year. The two exercise groups showed better quadriceps muscle strength, and VO at 4 months, compared to usual care.
This trial found no statistically significant effects of two exercise programs compared to usual care on KOOS QoL at 1 year in individuals with symptomatic and radiographic knee osteoarthritis, but an underpowered sample size may explain lack of efficacy between the intervention groups and the usual care group.
NCT01682980.
评估力量锻炼或有氧锻炼与常规护理相比，在 4 个月和 1 年时对膝骨关节炎患者膝关节相关生活质量（QoL）和膝关节功能的疗效。
一项三臂随机对照试验（RCT）将 12 周的力量锻炼或有氧锻炼（固定自行车）与由物理治疗师在初级保健中进行的常规护理进行比较。我们招募了 168 名年龄在 35-70 岁之间、有膝关节骨关节炎症状的参与者。主要结局是 1 年时的膝关节损伤和骨关节炎结果评分（KOOS）QoL。次要结局是在 4 个月和 1 年时的自我报告功能、疼痛和自我效能、肌肉力量和最大摄氧量（VO）。
在 1 年时，力量锻炼与常规护理在 KOOS QoL 方面（6.5，95%CI -0.9 至 14），或有氧锻炼与常规护理在 KOOS QoL 方面（5.0，95%CI -2.7 至 12.8）没有差异。与常规护理相比，两组锻炼组在 4 个月时表现出更好的股四头肌力量和 VO。
本试验发现，与常规护理相比，两种运动方案在 1 年时对有症状和放射影像学膝骨关节炎患者的 KOOS QoL 没有统计学上的显著效果，但样本量不足可能解释了干预组与常规护理组之间缺乏疗效。
NCT01682980。
