Aguglia Andrea, Natale Antimo, Conio Benedetta, De Michiel Clio Franziska, Lechiara Alessio, Pastorino Fabrizio, Fusar-Poli Laura, Costanza Alessandra, Amerio Andrea, Amore Mario, Serafini Gianluca
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, 16132 Genoa, Italy.
IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy.
J Clin Med. 2023 Aug 28;12(17):5621. doi: 10.3390/jcm12175621.
Cardiometabolic alterations are very common in bipolar disorder (BD). The aim of this study was to investigate the relationship between chronotype and cardiometabolic parameters in patients with a primary diagnosis of BD. This study is an observational clinical investigation including 170 subjects consecutively admitted to the Psychiatric Inpatient Unit of the IRCCS Ospedale Policlinico San Martino (Genoa, Italy), recruited over a period of 48 months. A psychometric tool assessing chronotype was administered and blood tests were performed. Furthermore, the atherogenic coefficient ((total cholesterol-HDL cholesterol)/HDL cholesterol), and Castelli risk index-I (total cholesterol/HDL cholesterol) and -II (LDL cholesterol/HDL cholesterol) were calculated. Patients with BD and an eveningness chronotype showed a higher body mass index, total and low-density lipotrotein cholesterol compared to patients with BD and an intermediate or morning chronotype. Furthermore, the Atherogenic Coefficient and Castelli Risk-Index I-II were found to be higher in bipolar patients with an evening chronotype. The role of chronotype in the development of obesity and cardiovascular risk is, therefore, a relationship worth being investigated, especially in the context of BD, to ameliorate the clinical and therapeutic approach, aiming at increasing the quality of life and reducing the mortality.
心脏代谢改变在双相情感障碍（BD）中非常常见。本研究的目的是调查初诊为BD的患者的昼夜节律类型与心脏代谢参数之间的关系。本研究是一项观察性临床调查，纳入了连续48个月期间在意大利热那亚IRCCS圣马蒂诺综合医院精神科住院部收治的170名受试者。使用了一种评估昼夜节律类型的心理测量工具并进行了血液检测。此外，计算了致动脉粥样硬化系数（（总胆固醇 - 高密度脂蛋白胆固醇）/高密度脂蛋白胆固醇）以及卡斯泰利风险指数 - I（总胆固醇/高密度脂蛋白胆固醇）和 - II（低密度脂蛋白胆固醇/高密度脂蛋白胆固醇）。与具有中间型或早晨型昼夜节律类型的BD患者相比，具有夜晚型昼夜节律类型的BD患者表现出更高的体重指数、总胆固醇和低密度脂蛋白胆固醇。此外，发现具有夜晚型昼夜节律类型的双相情感障碍患者的致动脉粥样硬化系数和卡斯泰利风险指数I - II更高。因此，昼夜节律类型在肥胖和心血管风险发展中的作用是一个值得研究的关系，特别是在双相情感障碍的背景下，以改善临床和治疗方法，旨在提高生活质量并降低死亡率。
