丙烯醛诱导小鼠阿尔茨海默病的视网膜异常。
Acrolein Induces Retinal Abnormalities of Alzheimer's Disease in Mice.
机构信息
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
Department of Ophthalmology, Affiliated Foshan Hospital, Southern Medical University, Foshan 528000, China.
出版信息
Int J Mol Sci. 2023 Sep 1;24(17):13576. doi: 10.3390/ijms241713576.
It is reported that retinal abnormities are related to Alzheimer's disease (AD) in patients and animal models. However, it is unclear whether the retinal abnormities appear in the mouse model of sporadic Alzheimer's disease (sAD) induced by acrolein. We investigated the alterations of retinal function and structure, the levels of β-amyloid (Aβ) and phosphorylated Tau (p-Tau) in the retina, and the changes in the retinal vascular system in this mouse model. We demonstrated that the levels of Aβ and p-Tau were increased in the retinas of mice from the acrolein groups. Subsequently, a decreased amplitudes of b-waves in the scotopic and photopic electroretinogram (ERG), decreased thicknesses of the retinal nerve fiber layer (RNFL) in the retina, and slight retinal venous beading were found in the mice induced by acrolein. We propose that sAD mice induced by acrolein showed abnormalities in the retina, which may provide a valuable reference for the study of the retina in sAD.
据报道，视网膜异常与患者和动物模型中的阿尔茨海默病（AD）有关。然而，目前尚不清楚丙烯醛诱导的散发性阿尔茨海默病（sAD）小鼠模型中是否存在视网膜异常。我们研究了该小鼠模型中视网膜功能和结构、β-淀粉样蛋白（Aβ）和磷酸化 Tau（p-Tau）水平以及视网膜血管系统的变化。结果表明，丙烯醛组小鼠视网膜中的 Aβ和 p-Tau 水平增加。随后，在丙烯醛诱导的小鼠中发现暗视和明视视网膜电图（ERG）的 b 波振幅降低，视网膜神经纤维层（RNFL）厚度变薄，视网膜静脉轻度珠状。我们提出，丙烯醛诱导的 sAD 小鼠的视网膜出现异常，这可能为 sAD 视网膜的研究提供有价值的参考。
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