Department of Chemistry and Chemical Biology, Rutgers - The State University of New Jersey, Piscataway, New Jersey, USA.
Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Biomed Mater Res A. 2020 Oct;108(10):1974-1990. doi: 10.1002/jbm.a.37059. Epub 2020 Aug 4.
The coronavirus disease 2019 (COVID-19) pandemic has revealed major shortcomings in our ability to mitigate transmission of infectious viral disease and provide treatment to patients, resulting in a public health crisis. Within months of the first reported case in China, the virus has spread worldwide at an unprecedented rate. COVID-19 illustrates that the biomaterials community was engaged in significant research efforts against bacteria and fungi with relatively little effort devoted to viruses. Accordingly, biomaterials scientists and engineers will have to participate in multidisciplinary antiviral research over the coming years. Although tissue engineering and regenerative medicine have historically dominated the field of biomaterials, current research holds promise for providing transformative solutions to viral outbreaks. To facilitate collaboration, it is imperative to establish a mutual language and adequate understanding between clinicians, industry partners, and research scientists. In this article, clinical perspectives are shared to clearly define emerging healthcare needs that can be met by biomaterials solutions. Strategies and opportunities for novel biomaterials intervention spanning diagnostics, treatment strategies, vaccines, and virus-deactivating surface coatings are discussed. Ultimately this review serves as a call for the biomaterials community to become a leading contributor to the prevention and management of the current and future viral outbreaks.
2019 年冠状病毒病（COVID-19）大流行暴露了我们减轻传染性病毒疾病传播和为患者提供治疗的能力的重大缺陷，导致了一场公共卫生危机。在中国首例报告病例后的数月内，该病毒以空前的速度在全球范围内传播。COVID-19 表明，生物材料界针对细菌和真菌开展了大量研究工作，但相对较少的努力用于病毒。因此，生物材料科学家和工程师在未来几年将不得不参与多学科抗病毒研究。尽管组织工程和再生医学在生物材料领域一直占据主导地位，但目前的研究有望为病毒爆发提供变革性的解决方案。为了促进合作，临床医生、行业合作伙伴和研究科学家之间必须建立共同的语言和充分的理解。本文分享了临床观点，以明确界定可以通过生物材料解决方案满足的新兴医疗保健需求。讨论了跨越诊断、治疗策略、疫苗和病毒灭活表面涂层的新型生物材料干预策略和机会。最终，这篇综述呼吁生物材料界成为预防和管理当前和未来病毒爆发的主要贡献者。
