Wang Xiao, Peng Hongxia, Xia Congying, Zhou Yunfeng, Shen Liqing, Cheng Xinran, Yang Chunxia, Yang Yanfang, Long Lu
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Epidemiology and Health Statistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan, China; Chengdu Shuangliu District Center for Disease Control and Prevention, Chengdu, Sichuan China.
Nutrition. 2023 Dec;116:112189. doi: 10.1016/j.nut.2023.112189. Epub 2023 Aug 7.
Future primary prevention strategies may benefit from understanding the connection between mortality in individuals with central obesity and modifiable lifestyle factors like dietary intake. This study sought to determine whether there was a separate relationship between folate, vitamin B, and vitamin B intake and all-cause and cause-specific mortality in the US population with central obesity.
The study analyzed data from the National Health and Nutrition Examination Survey between 1999 and 2016. Using the Cox proportional hazards model, the association between dietary intake of B vitamins and all-cause and cause-specific mortality was examined. A total of 7718 adults with central obesity were enrolled, with a mean age of 49.87 (SD = 0.25) y at baseline.
Folate intake was independently associated with a decreased incidence of all-cause mortality (adjusted hazard ratio = 0.71; 95% CI, 0.58-0.87). Furthermore, higher intake of vitamin B and vitamin B was inversely correlated with cardiovascular disease mortality (adjusted hazard ratio = 0.63; 95% CI, 0.40-0.98; and adjusted hazard ratio = 0.44; 95% CI, 0.29-0.65, respectively) and the finding reveal an interaction between homocysteine and vitamin B and folate on All-cause mortality CONCLUSIONS: The findings of this study suggest that vitamin B and folate intake may be protective factors in individuals with central obesity. It is important to consider both their total homocysteine level and body mass index in conjunction with these nutrients. Further research is needed to validate these findings.
未来的一级预防策略可能会从了解中心性肥胖个体的死亡率与可改变的生活方式因素（如饮食摄入）之间的联系中受益。本研究旨在确定在美国中心性肥胖人群中，叶酸、维生素B6和维生素B12的摄入量与全因死亡率和特定病因死亡率之间是否存在独立关系。
该研究分析了1999年至2016年美国国家健康和营养检查调查的数据。使用Cox比例风险模型，研究了B族维生素的饮食摄入量与全因死亡率和特定病因死亡率之间的关联。共纳入7718名中心性肥胖成年人，基线时平均年龄为49.87（标准差=0.25）岁。
叶酸摄入量与全因死亡率的降低独立相关（调整后的风险比=0.71；95%置信区间，0.58-0.87）。此外，较高的维生素B6和维生素B12摄入量与心血管疾病死亡率呈负相关（调整后的风险比分别为0.63；95%置信区间，0.40-0.98；以及调整后的风险比=0.44；95%置信区间，0.29-0.65），并且研究结果揭示了同型半胱氨酸与维生素B6和叶酸在全因死亡率方面存在相互作用。结论：本研究结果表明，维生素B6和叶酸摄入量可能是中心性肥胖个体的保护因素。结合这些营养素考虑其总同型半胱氨酸水平和体重指数很重要。需要进一步的研究来验证这些发现。
