Espírito-Santo Djane A, Cordeiro Gabriele S, Santos Lucimeire S, Silva Rafael T, Pereira Márcia U, Matos Rhowena Jane B, Boaventura Gilson T, Barreto-Medeiros Jairza Maria
Department of Nutrition, Graduate Program of Food Nutrition and Health, Federal University of Bahia, Brazil.
Department of Nutrition, Graduate Program of Food Nutrition and Health, Federal University of Bahia, Brazil.
Chem Biol Interact. 2023 Oct 1;384:110700. doi: 10.1016/j.cbi.2023.110700. Epub 2023 Sep 9.
Cardiovascular diseases (CVD) are the leading cause of death globally, estimated at 17.9 million premature deaths. Several risk factors contribute to the development of CVD, including unhealthy diet rich in saturated fat. Quercetin (Q) is a important natural flavonoid with cardioprotective effect. However, it is crucial to understand and clarify which dosages and intervention times quercetin promotes better cardioprotective effects when exposed to a High-Fat Diet (HFD). We aim was to carry out a review to identify and compare experimental studies that investigated the quercetin effect on cardiac parameters in rodents fed a HFD. This literature search was performed through the specialized databases PubMed, Embase, Web of Science and Lilacs in May 2022. The following information was collected and assessed: Species of animals, dietary fat content, intervention protocol (quercetin), and main results of alterations associated with cardiac change. A total of 116 articles were selected from the database and 30 articles were included in this study. The administration form of quercetin was used in the diet supplemented in 73.4% (n = 22) of the studies. The dosage ranged between 10 and 100 mg/kg, 0.01%-0.36%, and 4-8 g/kg diet. The treatment time ranged between 14 and 63 days in 48.4% studies and most of the selected studies observed changes in the: Serum concentrations of lipids (60%, n = 18) mainly decrease in TC and TG, left ventricle (LV) (16.13%, n = 5) includes attenuation of the cardiac hypertrophy; inhibition of atherosclerotic progression (32%, n = 10) with decrease in lesions and plaque formation; improvement in the expression of gene and protein associated with cardiac functionality and oxidative stress (51.6%; n = 16). Quercetin supplementation at different concentrations/doses promotes important cardioprotective effects in experimental models exposed to a HFD. The supplemented diet was shown to be the better administration option. The methodological variation presented in the articles selected in this review proves that the most appropriate intervention protocol, as well as the most effective route of administration, promotes these effects.
心血管疾病（CVD）是全球主要的死亡原因，估计导致1790万人过早死亡。多种风险因素会导致心血管疾病的发生，包括富含饱和脂肪的不健康饮食。槲皮素（Q）是一种具有心脏保护作用的重要天然黄酮类化合物。然而，了解和阐明在高脂饮食（HFD）条件下，槲皮素在何种剂量和干预时间能产生更好的心脏保护作用至关重要。我们的目的是进行一项综述，以识别和比较研究槲皮素对高脂饮食喂养的啮齿动物心脏参数影响的实验研究。2022年5月通过专业数据库PubMed、Embase、Web of Science和Lilacs进行了文献检索。收集并评估了以下信息：动物种类、饮食脂肪含量、干预方案（槲皮素）以及与心脏变化相关的主要改变结果。从数据库中总共筛选出116篇文章，本研究纳入了30篇文章。73.4%（n = 22）的研究采用在饮食中添加槲皮素的给药形式。剂量范围为10至100毫克/千克、0.01%至0.36%以及4至8克/千克饮食。48.4%的研究中治疗时间为14至63天，大多数所选研究观察到以下变化：血脂血清浓度（60%，n = 18），主要是总胆固醇（TC）和甘油三酯（TG）降低；左心室（LV）（16.13%，n = 5），包括心肌肥厚减轻；抑制动脉粥样硬化进展（32%，n = 10），病变和斑块形成减少；与心脏功能和氧化应激相关的基因和蛋白质表达改善（51.6%；n = 16）。在暴露于高脂饮食的实验模型中，补充不同浓度/剂量的槲皮素可产生重要的心脏保护作用。补充饮食被证明是更好的给药选择。本综述所选文章中呈现的方法学差异证明，最合适的干预方案以及最有效的给药途径可促进这些作用。
