Lu Di, Wu Jiu-Ping, Yang Qi-Wei, Wang Hua-Yi, Yang Jun-Jie, Zhang Gang-Gang, Wang Chen, Yang Yan-Lian, Zhu Ling, Sun Xin-Zhi
Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
CAS Key Laboratory of Standardization and Measurement for Nanotechnology, National Center for Nano-science and Technology, Beijing, China.
Front Bioeng Biotechnol. 2023 Aug 16;11:1261288. doi: 10.3389/fbioe.2023.1261288. eCollection 2023.
The effective regeneration and functional restoration of damaged spinal cord tissue have been a long-standing concern in regenerative medicine. Treatment of spinal cord injury (SCI) is challenging due to the obstruction of the blood-spinal cord barrier (BSCB), the lack of targeting of drugs, and the complex pathophysiology of injury sites. Lipid nanovesicles, including cell-derived nanovesicles and synthetic lipid nanovesicles, are highly biocompatible and can penetrate BSCB, and are therefore effective delivery systems for targeted treatment of SCI. We summarize the progress of lipid nanovesicles for the targeted treatment of SCI, discuss their advantages and challenges, and provide a perspective on the application of lipid nanovesicles for SCI treatment. Although most of the lipid nanovesicle-based therapy of SCI is still in preclinical studies, this low immunogenicity, low toxicity, and highly engineerable nanovesicles will hold great promise for future spinal cord injury treatments.
受损脊髓组织的有效再生和功能恢复一直是再生医学中长期关注的问题。由于血脊髓屏障（BSCB）的阻碍、药物靶向性的缺乏以及损伤部位复杂的病理生理学，脊髓损伤（SCI）的治疗具有挑战性。脂质纳米囊泡，包括细胞衍生的纳米囊泡和合成脂质纳米囊泡，具有高度的生物相容性，能够穿透血脊髓屏障，因此是用于脊髓损伤靶向治疗的有效递送系统。我们总结了脂质纳米囊泡用于脊髓损伤靶向治疗的进展，讨论了它们的优势和挑战，并对脂质纳米囊泡在脊髓损伤治疗中的应用提供了展望。尽管大多数基于脂质纳米囊泡的脊髓损伤治疗仍处于临床前研究阶段，但这种低免疫原性、低毒性且高度可工程化的纳米囊泡在未来脊髓损伤治疗中具有巨大潜力。
