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PTPN21在泛癌分析中的预后价值及免疫作用

Prognostic value and immunological role of PTPN21 in pan-cancer analysis.

作者信息

Yang YanE, Yang WenChao, Su Xingxing, Cheng CaiXia

机构信息

School of Public Health, Shanxi Medical University, China.

The First Clinical Medical College, Shanxi Medical University, China.

出版信息

Cent Eur J Immunol. 2023;48(2):111-125. doi: 10.5114/ceji.2023.129970. Epub 2023 Jul 20.

DOI:10.5114/ceji.2023.129970
PMID:37692032
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10485688/
Abstract

INTRODUCTION

At present, cancer remains a persistent public health challenge facing the whole world. Studies have found that PTPN21 is associated with the development of cancer. However, the prognostic potential of PTPN21 in pan-cancer remains unclear. In this work, we aimed to analyze the expression and prognostic value of PTPN21 in pan-cancer and to further study the relationship between PTPN21 and immune infiltration.

MATERIAL AND METHODS

TCGA and GEO data were used for expression and survival analysis. Genetic alterations in PTPN21 from TCGA cancer were studied in cBioPortal. TIMER2 was used to evaluate the correlation between PTPN21 expression and immune infiltration. The R packages "ggplot2" and "clusterProfiler" were used for GO and KEGG analysis.

RESULTS

PTPN21 was found to be a valuable diagnostic biomarker in multiple cancers, including bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and lung squamous cell carcinoma (LUSC). In addition, we observed that PTPN21 expression was associated with a variety of tumor mutations. Our results indicated a correlation between PTPN21 expression and immune infiltration. Enrichment analysis showed that PTPN21 was mainly involved in the regulation of neuroactive ligand-receptor interaction.

CONCLUSIONS

Our study showed that PTPN21 expression is associated with clinical prognosis, mutation, and immune infiltration of tumors. PTPN21 may be a potential biomarker for many cancers, especially in KIRC.

摘要

引言

目前，癌症仍然是全球面临的一个持续的公共卫生挑战。研究发现PTPN21与癌症的发生发展有关。然而，PTPN21在泛癌中的预后潜力仍不清楚。在这项工作中，我们旨在分析PTPN21在泛癌中的表达及预后价值，并进一步研究PTPN21与免疫浸润之间的关系。

材料与方法

使用TCGA和GEO数据进行表达和生存分析。在cBioPortal中研究了来自TCGA癌症的PTPN21基因改变。使用TIMER2评估PTPN21表达与免疫浸润之间的相关性。R包“ggplot2”和“clusterProfiler”用于GO和KEGG分析。

结果

发现PTPN21是多种癌症中有价值的诊断生物标志物，包括膀胱尿路上皮癌（BLCA）、肾透明细胞癌（KIRC）、肾乳头状细胞癌（KIRP）和肺鳞状细胞癌（LUSC）。此外，我们观察到PTPN21表达与多种肿瘤突变有关。我们的结果表明PTPN21表达与免疫浸润之间存在相关性。富集分析表明，PTPN21主要参与神经活性配体-受体相互作用的调节。

结论

我们的研究表明，PTPN21表达与肿瘤的临床预后、突变和免疫浸润有关。PTPN21可能是许多癌症的潜在生物标志物，尤其是在KIRC中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/10485688/3264b5e46f6b/CEJI-48-51128-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/10485688/3b77668ef7bd/CEJI-48-51128-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/10485688/cf8b6b1bcd51/CEJI-48-51128-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/10485688/3264b5e46f6b/CEJI-48-51128-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/10485688/3b77668ef7bd/CEJI-48-51128-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/317c/10485688/3264b5e46f6b/CEJI-48-51128-g007.jpg

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