Department of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, University of Warmia and Mazury in Olsztyn, Oczapowskiego 2, 10-719 Olsztyn, Poland.
Int J Environ Res Public Health. 2021 Oct 26;18(21):11251. doi: 10.3390/ijerph182111251.
In the course of plaque psoriasis, tissue resident memory cells (TRM) are responsible for the phenomenon of "immune memory" of lesions, i.e., the appearance of recurrences of lesions in the same location, as well as Koebner phenomenon. We present results determining the location and amount of TRM in psoriatic lesions in patients suffering from plaque psoriasis, as well as an analysis of the relationship between TRM markers expression and the duration and severity of the disease.
TRM markers (CD4, CD8, CD103, CD69, CD49, CXCR6) and tissue expression of cytokines (IL-17, IL-22) in the lesional psoriatic skin of 32 patients compared with 10 healthy skin samples were evaluated by immunohistochemistry.
The presence of TRM markers in both the epidermis and skin with psoriatic eruptions was demonstrated in much higher amounts compared with the skin of healthy volunteers. A significant positive relationship was demonstrated between the expression of TRM markers in patients with plaque psoriasis and the duration of skin lesions. There was no relationship between the amount of TRM and the severity of plaque psoriasis.
A thorough understanding of the mechanisms responsible for the development and relapse of plaque psoriasis may contribute to the implementation of more effective therapies.
在斑块型银屑病的发展过程中，组织驻留记忆细胞（TRM）负责病变的“免疫记忆”现象，即同一部位病变的复发，以及科布纳现象。我们介绍了在斑块型银屑病患者的银屑病皮损中确定 TRM 位置和数量的结果，以及分析 TRM 标志物表达与疾病持续时间和严重程度之间的关系。
通过免疫组织化学法比较 32 名患者的病变银屑病皮肤与 10 名健康皮肤样本中 TRM 标志物（CD4、CD8、CD103、CD69、CD49、CXCR6）和组织细胞因子（IL-17、IL-22）的表达。
与健康志愿者的皮肤相比，在银屑病皮损的表皮和皮肤中均显示出更高数量的 TRM 标志物存在。在斑块型银屑病患者中，TRM 标志物的表达与皮肤损伤的持续时间呈显著正相关。TRM 的数量与斑块型银屑病的严重程度之间没有关系。
深入了解导致斑块型银屑病发展和复发的机制可能有助于实施更有效的治疗方法。
