Huo Yi-Shan, Chen Zhao-Yi, Yin Xue-Jiao, Jiang Tong-Fei, Wang Gui-Ling, Cui Ying-Xue, Guo Jing
Acupuncture-Moxibustion Center, Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100010, China; Department of TCM, First Affiliated Hospital of Tsinghua University, Beijing 100016.
Acupuncture-Moxibustion Center, Beijing Hospital of TCM Affiliated to Capital Medical University, Beijing 100010, China.
Zhongguo Zhen Jiu. 2023 Sep 12;43(9):1008-13. doi: 10.13703/j.0255-2930.20221120-0001.
To observe the effects of (regulating the spirit) acupuncture on cognitive function and sleep quality in patients with primary insomnia (PI).
Sixty patients with PI were randomly divided into an observation group (30 cases, 2 cases dropped off) and a control group (30 cases, 2 cases dropped off, 1 case was excluded). The patients in the observation group were treated with acupuncture at Baihui (GV 20), Shenting (GV 24), Sishencong (EX-HN 1), and bilateral Benshen (GB 13), Shenmen (HT 7), Neiguan (PC 6), Sanyinjiao (SP 6). The patients in the control group were treated with shallow needling at non-effective points. Each treatment was provided for 30 min, once every other day, 3 treatments per week for 4 weeks. The Montreal cognitive assessment (MoCA), digit span test (DST), trail making test (TMT)-A, Pittsburgh sleep quality index (PSQI), and fatigue scale-14 (FS-14) were used to assess cognitive function and sleep quality before and after treatment, as well as in follow-up of 4-week after treatment completion. Correlation analysis was conducted between the differences in PSQI scores and differences in MoCA scores before and after treatment in the observation group.
Compared with before treatment, the total score, visuospatial and executive function score and delayed memory score of MoCA as well as DST backward score were increased (<0.01), while TMT-A time, PSQI and FS-14 scores were significantly reduced (<0.01) after treatment and in follow-up in the observation group. Compared with before treatment, the PSQI score in the control group was reduced (<0.01, <0.05). After treatment and in follow-up, the observation group had significantly higher total score, visuospatial and executive function score, delayed memory score of MoCA, and DST backward score compared to the control group (<0.05, <0.01). In the observation group, the TMT-A time was significantly shorter than that in the control group (<0.05, <0.01), and the PSQI and FS-14 scores were significantly lower than those in the control group (<0.01). In the observation group, there was a negative correlation between the difference in PSQI scores (post-treatment minus pre-treatment) and the difference in MoCA scores (post-treatment minus pre-treatment) (=-0.481, <0.01). A similar negative correlation was found between the difference in PSQI scores (follow-up minus pre-treatment) and the difference in MoCA scores (follow-up minus pre-treatment) (=-0.282, <0.05).
acupuncture could improve cognitive function, enhance sleep quality, and alleviate daytime fatigue in patients with PI. The improvement in cognitive function in patients with PI is correlated with the improvement in sleep quality.
观察调神针刺法对原发性失眠（PI）患者认知功能和睡眠质量的影响。
将60例PI患者随机分为观察组（30例，脱落2例）和对照组（30例，脱落2例，剔除1例）。观察组患者采用针刺百会（GV 20）、神庭（GV 24）、四神聪（EX-HN 1）及双侧本神（GB 13）、神门（HT 7）、内关（PC 6）、三阴交（SP 6）治疗。对照组患者采用非经穴浅刺治疗。每次治疗30分钟，隔日1次，每周治疗3次，共治疗4周。采用蒙特利尔认知评估量表（MoCA）、数字广度测验（DST）、连线测验（TMT）-A、匹兹堡睡眠质量指数（PSQI）及疲劳量表-14（FS-14）评估治疗前、治疗后及治疗结束后4周随访时的认知功能和睡眠质量。对观察组治疗前后PSQI评分差值与MoCA评分差值进行相关性分析。
观察组治疗后及随访时，与治疗前比较，MoCA总分、视空间与执行功能评分、延迟记忆评分及DST倒背分数升高（<0.01），TMT-A时间、PSQI及FS-14评分显著降低（<0.01）。对照组治疗后与治疗前比较，PSQI评分降低（<0.01，<0.05）。治疗后及随访时，观察组MoCA总分、视空间与执行功能评分、延迟记忆评分及DST倒背分数显著高于对照组（<0.05，<0.01）。观察组TMT-A时间显著短于对照组（<0.05，<0.01），PSQI及FS-14评分显著低于对照组（<0.01）。观察组治疗前后PSQI评分差值与MoCA评分差值呈负相关（=-0.481，<0.01）。随访与治疗前PSQI评分差值与MoCA评分差值也呈类似负相关（=-0.282，<0.05）。
调神针刺法可改善PI患者的认知功能，提高睡眠质量，减轻日间疲劳。PI患者认知功能的改善与睡眠质量的提高相关。
