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全球、区域和国家范围内,204 个国家和地区 1990 年至 2019 年期间老年人群高血压性心脏病负担分析:趋势分析。

Global, regional, and national burden of hypertensive heart disease among older adults in 204 countries and territories between 1990 and 2019: a trend analysis.

机构信息

Hypertension Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.

出版信息

Chin Med J (Engl). 2023 Oct 20;136(20):2421-2430. doi: 10.1097/CM9.0000000000002863. Epub 2023 Sep 12.

Abstract

BACKGROUND

Hypertensive heart disease (HHD) poses a public health challenge, but data on its burden and trends among older adults are scarce. This study aimed to identify trends in the burden of HHD among older adults between 1990 and 2019 at the global, regional, and national levels.

METHODS

Using the Global Burden of Diseases study 2019 data, we assessed HHD prevalence, death, and disability-adjusted life-year (DALY) rates for individuals aged 60-89 years at the global, regional, and national levels and estimated their average annual percentage changes (AAPCs) between 1990 and 2019 using joinpoint regression analysis.

RESULTS

In 2019, there were 14.35 million HHD prevalent cases, 0.85 million deaths, and 14.56 million DALYs in older adults. Between 1990 and 2019, the prevalence of HHD increased globally {AAPC, 0.38 (95% confidence interval [CI], 0.36, 0.41)} with decreases observed in mortality (AAPC, -0.83 [95% CI, -0.99, -0.66]) and the DALY rate (AAPC, -1.03 [95% CI, -1.19, -0.87]). This overall global trend pattern was essentially maintained for sex, age group, and sociodemographic index (SDI) quintile except for non-significant changes in the prevalence of HHD in those aged 70-74 years and in the middle SDI quintile. Notably, males had a higher HHD prevalence rate. However, HHD-related mortality and the DALY rate were higher in females. The middle SDI quintile experienced the largest decreases in mortality and the DALY rate, with a non-significant decline in prevalence between 1990 and 2019. There were significant discrepancies in the HHD burden and its trends across regions and countries.

CONCLUSIONS

In the past three decades, there has been an overall increasing trend in the prevalence of HHD among older adults worldwide despite decreasing trends in mortality and the DALY rate. Better management of hypertension, and prevention and control of HHD are needed in older adults.

摘要

背景

高血压性心脏病(HHD)对公共健康构成挑战,但关于老年人 HHD 负担和趋势的数据却很少。本研究旨在确定全球、区域和国家层面 60-89 岁老年人 HHD 负担的趋势。

方法

使用全球疾病负担研究 2019 年的数据,我们评估了全球、区域和国家层面 60-89 岁人群的 HHD 患病率、死亡和伤残调整生命年(DALY)率,并使用 Joinpoint 回归分析估计了 1990 年至 2019 年之间的平均年变化百分比(AAPC)。

结果

2019 年,老年人中有 1435 万例 HHD 现患病例、85 万例死亡和 1456 万例 DALY。1990 年至 2019 年期间,HHD 的全球患病率呈上升趋势(AAPC,0.38[95%置信区间(CI):0.36,0.41]),而死亡率(AAPC,-0.83[95%CI:-0.99,-0.66])和 DALY 率(AAPC,-1.03[95%CI:-1.19,-0.87])则呈下降趋势。除了 70-74 岁年龄组和中社会人口指数(SDI)五分位数的 HHD 现患率无显著变化外,全球这一总体趋势模式在性别、年龄组和 SDI 五分位数上基本保持不变。值得注意的是,男性的 HHD 现患率较高。然而,女性的 HHD 相关死亡率和 DALY 率更高。中 SDI 五分位数的死亡率和 DALY 率降幅最大,1990 年至 2019 年期间 HHD 现患率无显著下降。不同地区和国家的 HHD 负担及其趋势存在显著差异。

结论

在过去的三十年中,尽管死亡率和 DALY 率呈下降趋势,但全球 60-89 岁老年人 HHD 的患病率总体呈上升趋势。需要更好地管理高血压和预防控制 HHD。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f502/10586836/0baf91b050cd/cm9-136-2421-g001.jpg

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