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异常的血液微生物群谱与 HIV/AIDS 个体的炎症和免疫恢复有关。

Abnormal blood microbiota profiles are associated with inflammation and immune restoration in HIV/AIDS individuals.

机构信息

Senior Department of Infectious Diseases, The Fifth Medical Center of Chinese PLA General Hospital, National Clinical Research Center for Infectious Diseases , Beijing, China.

Department of Gastroenterology, First Medical Center of Chinese PLA General Hospital , Beijing, China.

出版信息

mSystems. 2023 Oct 26;8(5):e0046723. doi: 10.1128/msystems.00467-23. Epub 2023 Sep 12.

DOI:10.1128/msystems.00467-23
PMID:37698407
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10654078/
Abstract

The characteristics of blood microbiota in HIV-infected individuals and their relevance to disease progression are still unknown, despite alterations in gut microbiota diversity and composition in HIV-infected individuals. Here, we present evidence of increased blood microbiota diversity in HIV-infected individuals, which may result from gut microbiota translocation. Also, we identify a group of microbes, , sp. , sp. , , , sp. , and , which are linked to poor immunological recovery. This work provides a scientific foundation toward therapeutic strategies targeting blood microbiota for immune recovery of HIV infection.

摘要

尽管 HIV 感染者的肠道微生物多样性和组成发生了改变，但 HIV 感染者血液微生物组的特征及其与疾病进展的关系仍不清楚。在这里，我们提出了 HIV 感染者血液微生物组多样性增加的证据，这可能是由于肠道微生物群移位所致。此外，我们还确定了一组微生物，即，，，，，，，和，它们与免疫恢复不良有关。这项工作为针对 HIV 感染的血液微生物组的免疫恢复的治疗策略提供了科学基础。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/ea5df379866f/msystems.00467-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/50e2b4352459/msystems.00467-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/c73b0d062e8f/msystems.00467-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/fb3c10681932/msystems.00467-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/2fbad734a651/msystems.00467-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/d786f16407ce/msystems.00467-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/ea5df379866f/msystems.00467-23.f006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/50e2b4352459/msystems.00467-23.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/c73b0d062e8f/msystems.00467-23.f002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/fb3c10681932/msystems.00467-23.f003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/2fbad734a651/msystems.00467-23.f004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/d786f16407ce/msystems.00467-23.f005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6f53/10654078/ea5df379866f/msystems.00467-23.f006.jpg

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