Kong Qing-Zhou, Peng Cheng, Li Zhen, Tian Bao-Ling, Li Yue-Yue, Chen Fei-Xue, Zuo Xiu-Li, Li Yan-Qing
Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan, Shandong, China.
Shandong Provincial Clinical Research Center for Digestive Disease, Jinan, Shandong, China.
Front Pharmacol. 2023 Aug 28;14:1184754. doi: 10.3389/fphar.2023.1184754. eCollection 2023.
To explore factors associated with inadequate gastric preparation for MCE. Factors associated with inadequate gastric preparation for magnetically controlled capsule endoscopy (MCE) remains unclear. Data of patients who underwent MCE from June 2021 to July 2022 were prospectively collected. The gastric cleanliness score (GCS) of the six stomach regions (gastric cardia, fundus, body, angulus, antrum, and pylorus) was recorded. Patients with GCS score ≥18 were defined as the adequate preparation. Factors related to inadequate gastric preparation were analyzed using a logistic regression model with estimated odds ratios (OR). The mean GCS score of 211 patients was 17.01 ± 2.82. In the multivariable analysis, proton pump inhibitor (PPI) use (OR 3.57; 95% CI 1.69-7.95; < 0.01) and premedication time after administering simethicone <30 min (OR 2.86; 95% CI 1.10-7.39; = 0.03) were independent risk factors for inadequate gastric preparation. Comparing the gastric cleanliness of different locations, the median GCS of the lower stomach [10.00, IQR (9.50, 11.00)] was significantly higher than that of the upper stomach [7.00, IQR (6.00, 8.00)] ( <0.001). PPI use and inadequate premedication time (<30 min) may reduce the quality of gastric preparation for MCE. The type, dose, duration of medication, and discontinuation time of PPIs was well worth further exploration. Appropriate control of the type and time of premedication may be the key to improving overall gastric cleanliness.
探讨与磁控胶囊内镜检查（MCE）胃准备不充分相关的因素。与磁控胶囊内镜检查（MCE）胃准备不充分相关的因素尚不清楚。前瞻性收集了2021年6月至2022年7月接受MCE的患者数据。记录六个胃区域（贲门、胃底、胃体、胃角、胃窦和幽门）的胃清洁度评分（GCS）。GCS评分≥18分的患者被定义为准备充分。使用逻辑回归模型和估计比值比（OR）分析与胃准备不充分相关的因素。211例患者的平均GCS评分为17.01±2.82。在多变量分析中，使用质子泵抑制剂（PPI）（OR 3.57；95%CI 1.69-7.95；P<0.01）和服用西甲硅油后的预处理时间<30分钟（OR 2.86；95%CI 1.10-7.39；P=0.03）是胃准备不充分的独立危险因素。比较不同部位的胃清洁度，胃下部的GCS中位数[10.00，IQR（9.50，11.00）]显著高于胃上部[7.00，IQR（6.00，8.00）]（P<0.001）。使用PPI和预处理时间不足（<30分钟）可能会降低MCE胃准备的质量。PPI的类型、剂量、用药持续时间和停药时间非常值得进一步探索。适当控制预处理的类型和时间可能是提高整体胃清洁度的关键。
