磁控胶囊内镜检查前的胃部准备：一项前瞻性、随机、单盲对照临床试验。

Gastric preparation for magnetically controlled capsule endoscopy: A prospective, randomized single-blinded controlled trial.

机构信息

Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China.

Department of Gastroenterology, Royal Hallamshire Hospital, Sheffield Teaching Hospitals NHS Trust, UK.

出版信息

Dig Liver Dis. 2018 Jan;50(1):42-47. doi: 10.1016/j.dld.2017.09.129. Epub 2017 Oct 6.

DOI:10.1016/j.dld.2017.09.129

PMID:29110963

Abstract

BACKGROUND AND AIMS

Magnetically controlled capsule endoscopy (MCE) is a novel technique for which there is no agreed gastric preparation. We aimed to determine an optimal standardized gastric preparation regimen.

METHODS

120 patients referred for MCE were randomly assigned to gastric preparation with either water alone (A), water with simethicone (B) or water, simethicone and pronase (C). Image quality was assessed using cleanliness and visualization scores, higher scores equating to better image quality.

RESULTS

The total cleanliness scores were (mean±SD) 15.83±2.41 (A), 21.35±1.23 (B), and 20.82±1.90 (C). The total visualization scores (mean±SD) were 10.75±2.02 (A), 15.20±1.32 (B), and 15.08±1.86 (C). While the image quality of the whole stomach in groups B and C were significantly better than group A (P<0.0001), there was no statistical difference between group B and C (P>0.05). MCE detected positive findings in 21 (52.5%), 27 (67.5%) and 21 (53.8%) patients in group A, B and C respectively, with no significant difference between groups (P>0.5).

CONCLUSIONS

Simethicone swallowed with water prior to MCE produced the optimal gastric mucosal image quality. The addition of pronase had no demonstrable additional benefit.

摘要

背景与目的

磁控胶囊内镜（MCE）是一种新的技术，目前尚未达成一致的胃准备方案。本研究旨在确定一种最佳的标准化胃准备方案。

方法

120 例接受 MCE 检查的患者被随机分为三组，分别接受清水（A 组）、清水加二甲硅油（B 组）或清水、二甲硅油加胰酶（C 组）进行胃准备。通过清洁度和可视化评分评估图像质量，评分越高表示图像质量越好。

结果

总清洁度评分分别为（均值±标准差）15.83±2.41（A 组）、21.35±1.23（B 组）和 20.82±1.90（C 组）。总可视化评分分别为 10.75±2.02（A 组）、15.20±1.32（B 组）和 15.08±1.86（C 组）。B 组和 C 组的整个胃图像质量明显优于 A 组（P<0.0001），但 B 组和 C 组之间无统计学差异（P>0.05）。A、B 和 C 组 MCE 分别检出阳性发现 21 例（52.5%）、27 例（67.5%）和 21 例（53.8%），组间差异无统计学意义（P>0.5）。