Peng Juan, Wei Qiang, Zhou Shibo, Gu Zhutong, Lv Kangtai
Department of Ultrasound, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Department of Ultrasound, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, China.
Transl Cancer Res. 2023 Aug 31;12(8):2138-2154. doi: 10.21037/tcr-23-1135. Epub 2023 Aug 28.
Breast cancer (BRCA) is the malignant tumor with the highest incidence rate among women in the world, and its mortality rate ranks second. The purpose of our study is to explore the correlation between caspase-1 () and the prognosis of BRCA patients and the potential mechanism of action, and to analyze the clinical value of combined with multimodal ultrasound features in early screening and prognosis of BRCA.
We analyzed The Cancer Genome Atlas (TCGA) database to confirm that was expressed in BRCA patients and determine whether its expression was correlated with patient prognosis. The relationship between expression and survival was measured by the clinicopathological parameters. Multivariate analysis was performed using Cox regression, and a nomogram was developed using these results for quality assurance purposes. The correlations between and immune cells were investigated using the Tumor Immune Estimation Resource (TIMER) and TCGA databases. Next, we performed gene set enrichment analysis (GSEA) to determine the potential mechanism of action. Finally, to analyze the effect of combined with multimodal ultrasonography characteristics on the prognosis of BRCA patients was studied by analyzing the clinical data of patients.
expression was lower in BRCA tumor tissues than in the surrounding tissues. Patients with high expression had better overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) than those with low expression. GSEA suggested that may affect the cell cycle, immune environment, inflammation, apoptosis, the HIPPOMERLIN pathway, Natural killer (NK) cell regulation of cytotoxicity, p53 expression, the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway, the mitogen-activated protein kinase (MAPK) pathway, extracellular matrix, etc., thereby influencing the biological events in BRCA. Among conventional ultrasound features and contrast-enhanced ultrasound (CEUS) features, mass margin status and blood flow grade were associated with the expression of . Meanwhile, patients with poor ultrasound features tended to have low expression.
may be a novel predictive marker for BRCA patients. combined with multimodal ultrasound features has good clinical value in the early screening and prognostic prediction of BRCA.
乳腺癌（BRCA）是全球女性中发病率最高的恶性肿瘤，其死亡率位居第二。本研究的目的是探讨半胱天冬酶 -1（）与BRCA患者预后的相关性及其潜在作用机制，并分析其联合多模态超声特征在BRCA早期筛查和预后中的临床价值。
我们分析了癌症基因组图谱（TCGA）数据库，以确认其在BRCA患者中的表达情况，并确定其表达是否与患者预后相关。通过临床病理参数测量其表达与生存之间的关系。使用Cox回归进行多变量分析，并利用这些结果绘制列线图以确保质量。使用肿瘤免疫评估资源（TIMER）和TCGA数据库研究其与免疫细胞之间的相关性。接下来，我们进行基因集富集分析（GSEA）以确定潜在的作用机制。最后，通过分析患者的临床数据，研究其联合多模态超声特征对BRCA患者预后的影响。
BRCA肿瘤组织中的表达低于周围组织。高表达患者的总生存期（OS）、疾病特异性生存期（DSS）和无进展生存期（PFI）均优于低表达患者。GSEA表明，其可能影响细胞周期、免疫环境、炎症、凋亡、HIPPOMERLIN通路、自然杀伤（NK）细胞的细胞毒性调节、p53表达、Janus激酶 - 信号转导和转录激活因子（JAK - STAT）通路、丝裂原活化蛋白激酶（MAPK）通路、细胞外基质等，从而影响BRCA中的生物学事件。在传统超声特征和超声造影（CEUS）特征中，肿块边缘状态和血流分级与的表达相关。同时，超声特征较差的患者往往表达较低。
可能是BRCA患者的一种新型预测标志物。其联合多模态超声特征在BRCA的早期筛查和预后预测中具有良好的临床价值。
