Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, China.
Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
J Med Virol. 2023 Sep;95(9):e29088. doi: 10.1002/jmv.29088.
Bladder cancer (BC) is a complex disease affecting the urinary system and is regulated by several carcinogenic factors. Viral infection is one such factor that has attracted extensive attention in BC. Human papillomavirus (HPV) is the most common sexually transmitted infection, and although multiple researchers have explored the role of HPV in BC, a consensus has not yet been reached. In addition, HPV-associated viruses (e.g., human immunodeficiency virus, herpes simplex virus, BK virus, and JC virus) appear to be responsible for the occurrence and progression of BC. This study systematically reviews the relationship between HPV-associated viruses and BC to elucidate the role of these viruses in the onset and progression of BC. In addition, the study aims to provide a greater insight into the biology of HPV-associated viruses, and assess potential strategies for treating virus-induced BC. The study additionally focuses on the rapid development of oncolytic viruses that provide a potentially novel option for the treatment of BC.
膀胱癌（BC）是一种影响泌尿系统的复杂疾病，受多种致癌因素调控。病毒感染就是其中一个引起广泛关注的因素。人乳头瘤病毒（HPV）是最常见的性传播感染，尽管许多研究人员已经探索了 HPV 在 BC 中的作用，但尚未达成共识。此外，HPV 相关病毒（如人类免疫缺陷病毒、单纯疱疹病毒、BK 病毒和 JC 病毒）似乎与 BC 的发生和发展有关。本研究系统地综述了 HPV 相关病毒与 BC 之间的关系，以阐明这些病毒在 BC 发病和进展中的作用。此外，本研究旨在更深入地了解 HPV 相关病毒的生物学特性，并评估治疗病毒诱导的 BC 的潜在策略。本研究还重点关注溶瘤病毒的快速发展，为 BC 的治疗提供了一种潜在的新选择。
