两例广泛耐药（XDR）感染病例，合并头孢曲松耐药和高水平阿奇霉素耐药，法国，2022 年 11 月和 2023 年 5 月。

Two cases of extensively drug-resistant (XDR) infection combining ceftriaxone-resistance and high-level azithromycin resistance, France, November 2022 and May 2023.

机构信息

Paris Cité University, INSERM1137, IAME, Paris, France.

These authors contributed equally to this work and share first authorship.

出版信息

Euro Surveill. 2023 Sep;28(37). doi: 10.2807/1560-7917.ES.2023.28.37.2300456.

DOI:10.2807/1560-7917.ES.2023.28.37.2300456

PMID:37707979

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10687985/

Abstract

We report two extensively drug-resistant (XDR) (NG) isolates combining high-level resistance to azithromycin and resistance to ceftriaxone, obtained in France from two heterosexual patients, one of whom returned from Cambodia. Whole genome sequencing identified MLST ST16406, the mosaic -60.001 which caused ceftriaxone resistance in the internationally spreading FC428 clone, and the A2059G mutation in the 23S rRNA gene. The NG isolates F93 and F94 were related to XDR isolates detected in Austria and the United Kingdom in 2022.

摘要

我们报告了两株广泛耐药（XDR）（NG）分离株，它们对阿奇霉素具有高水平耐药性，并对头孢曲松耐药，这两株分离株均从法国的两名异性恋患者中获得，其中一名患者从柬埔寨返回。全基因组测序鉴定出 MLST ST16406 型，这是导致国际传播 FC428 克隆头孢曲松耐药的马赛克-60.001，以及 23S rRNA 基因中的 A2059G 突变。NG 分离株 F93 和 F94 与 2022 年在奥地利和英国检测到的 XDR 分离株有关。