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基于 DNA 链置换反应的三输入逻辑门。

Three-input logic gate based on DNA strand displacement reaction.

机构信息

School of Statistics, Shanxi University of Finance and Economy, Taiyuan, 030000, China.

出版信息

Sci Rep. 2023 Sep 14;13(1):15210. doi: 10.1038/s41598-023-42383-9.

DOI:10.1038/s41598-023-42383-9
PMID:37709846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10502070/
Abstract

In this paper, three kinds of three-input logic gates are designed based on DNA strand displacement reaction, which are three-input OR logic gate, three-input AND logic gate, and three-input MAJORITY logic gate. The logic gates designed in this paper takes different DNA strands as input and fluorescence signals as output. The biochemical experimental results verify my designs. The results show that DNA strand displacement technology has important application value in DNA computing, especially in the construction of DNA molecular logic gates.

摘要

本文基于 DNA 链置换反应设计了三种三输入逻辑门,分别是三输入或逻辑门、三输入与逻辑门和三输入 majority 逻辑门。本文设计的逻辑门以不同的 DNA 链作为输入,荧光信号作为输出。生物化学实验结果验证了设计的合理性。结果表明,DNA 链置换技术在 DNA 计算中具有重要的应用价值,特别是在 DNA 分子逻辑门的构建中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/69deb5f3e381/41598_2023_42383_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/73546f2b7cec/41598_2023_42383_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/8ba5e508f8e2/41598_2023_42383_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/33451208362e/41598_2023_42383_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/70433593709b/41598_2023_42383_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/0f29384fe861/41598_2023_42383_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/69deb5f3e381/41598_2023_42383_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/73546f2b7cec/41598_2023_42383_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/8ba5e508f8e2/41598_2023_42383_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/33451208362e/41598_2023_42383_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/70433593709b/41598_2023_42383_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/0f29384fe861/41598_2023_42383_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2fed/10502070/69deb5f3e381/41598_2023_42383_Fig6_HTML.jpg

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本文引用的文献

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利用智能 DNA 纳米机器人靶向核仁素阻碍血管生成。
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Three-input majority logic gate and multiple input logic circuit based on DNA strand displacement.基于 DNA 链置换的三输入多数逻辑门和多输入逻辑电路。
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