原发性青光眼对中国人群健康相关生活质量的影响：邯郸眼病研究。
Impact of primary glaucoma on health-related quality of life in China: the handan eye study.
机构信息
National Clinical Research Center for Eye Diseases, The Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
The First People's Hospital of Huzhou, The First Affiliated Hospital of Huzhou Teacher College, Huzhou, Zhejiang, China.
出版信息
BMC Ophthalmol. 2023 Sep 14;23(1):377. doi: 10.1186/s12886-023-03106-w.
BACKGROUND
We assessed health-related quality of life (HRQOL) and its determinants among rural glaucoma participants compared to age-matched normal controls in the population-based Handan Eye Study (HES), in rural Yongnian County, northern China.
METHODS
We enrolled 99 adults with glaucoma (mean age 63.0 ± 11.0 years), including primary open-angle glaucoma (POAG, n = 67) and primary angle-closure glaucoma (PACG, n = 32) and 102 controls (mean age 58.5 ± 5.3 years) with normal visual acuity and visual field and no history of glaucoma. Results of ophthalmic examinations and socioeconomic data were recorded. HRQOL was measured using the EQ-5D (converted to utility valves, UVs), and visual function (VF) and vision-related quality of life (VRQOL) were evaluated using the visual function-quality of life (VF-QOL) instrument.
PRIMARY AND SECONDARY OUTCOME MEASURES
EQ-5D and VF-QOL scores.
RESULTS
The mean UVs, VF, and VRQOL scores for glaucoma cases were 0.98 ± 0.04, 87.9 ± 15.2, and 95.5 ± 12.8, respectively, significantly worse than VF (94.4 ± 4.4) and VRQOL (100.0 ± 0.0) among controls, even after adjusting for age, gender, educational level, and family income (P = 0.015, P = 0.033). UVs were significantly lower among glaucoma participants with impaired VRQOL (55.4 ± 11.5) compared to those with normal VRQOL scores (99.1 ± 2.8) (UVs: 0.92 ± 0.08 vs. 0.99 ± 0.03, P = 0.036), also after adjustment for age and family income (P = 0.006). Participants with PACG had significantly lower VF and VRQOL scores compared to POAG (77.8 ± 21.4 vs. 92.9 ± 6.8, P < 0.001; 89.0 ± 18.1 vs. 98.7 ± 7.5, P < 0.001).
CONCLUSION
Participants with glaucoma have worse visual function and related quality of life compared to age-matched normal population controls. Participants with PACG have lower VF and VRQOL compared to those with POAG. UVs can be used for cost-effectiveness research and to support public health strategies for glaucoma in rural China.
背景
我们评估了农村青光眼患者的健康相关生活质量（HRQOL）及其决定因素，这些患者与中国北方永年县农村人群为基础的邯郸眼病研究（HES）中的年龄匹配的正常对照组进行了比较。
方法
我们招募了 99 名青光眼患者（平均年龄 63.0±11.0 岁），包括原发性开角型青光眼（POAG，n=67）和原发性闭角型青光眼（PACG，n=32），以及 102 名对照组（平均年龄 58.5±5.3 岁），这些对照组的视力和视野正常，没有青光眼病史。记录了眼科检查和社会经济数据。使用 EQ-5D（转换为效用值，UVs）测量 HRQOL，使用视觉功能-生活质量（VF-QOL）工具评估视觉功能（VF）和与视觉相关的生活质量（VRQOL）。
主要和次要结局指标
EQ-5D 和 VF-QOL 评分。
结果
青光眼患者的平均 UVs、VF 和 VRQOL 评分分别为 0.98±0.04、87.9±15.2 和 95.5±12.8，明显低于对照组的 VF（94.4±4.4）和 VRQOL（100.0±0.0），即使在校正了年龄、性别、教育水平和家庭收入后也是如此（P=0.015，P=0.033）。与 VRQOL 正常的患者相比，VRQOL 受损的青光眼患者的 UVs 明显更低（55.4±11.5）（UVs：0.92±0.08 比 0.99±0.03，P=0.036），即使在校正了年龄和家庭收入后也是如此（P=0.006）。PACG 患者的 VF 和 VRQOL 评分明显低于 POAG（77.8±21.4 比 92.9±6.8，P<0.001；89.0±18.1 比 98.7±7.5，P<0.001）。
结论
与年龄匹配的正常人群对照组相比，青光眼患者的视觉功能和相关生活质量更差。与 POAG 患者相比，PACG 患者的 VF 和 VRQOL 更低。UVs 可用于成本效益研究，并支持中国农村地区青光眼的公共卫生策略。
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