Gao Jianlu, Liang Yuanbo, Wang Fenghua, Shen Ran, Wong Tienyin, Peng Yi, Friedman David S, Wang Ningli
1] Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing, China [2] Liaocheng Clinical Hospital, Taishan Medical College, Shandong Province, China.
Beijing Tongren Eye Center, Capital University of Medical Sciences, Beijing, China.
Sci Rep. 2015 Apr 30;5:9585. doi: 10.1038/srep09585.
Glaucoma is the second leading cause of blindness worldwide. To examine the relationship between angle closure and the retinal vessel diameter in Chinese adults, we conducted Handan Eye Study (HES), a large population-based cross-sectional study, which enrolled 6830 participants >30 year-old living in 13 randomly selected villages of Yongnian County. After adjusting for age, gender, spherical equivalent (SE), diabetes, and hypertension, the mean central retinal artery equivalent (CRAE, μm) was 127.1 ± 7.0 and 145.6 ± 4.4 in primary open-angle glaucoma (POAG) and primary angle closure glaucoma (PACG), respectively; narrower than that in normal control (156.1 ± 0.4), primary angle-closure suspect (PACS) (156.3 ± 1.1) or primary angle closure (PAC) (156.0 ± 3.4) (P = 0.001). The mean central retinal vein equivalent (CRVE, μm) was 229.0 ± 5.9 and 215.8 ± 9.5 in POAG and PACG, respectively; narrower than that in normal control (238.3 ± 0.5), PACS (241.2 ± 1.4) or PAC (242.2 ± 4.6) (P = 0.001). There was no significant difference in the mean CRAE or CRVE between PACG and POAG. Compared to the normal control (0.66), the mean arterio-venous ratio (AVR) was smaller in POAG (0.64) and PACG (0.59), whereas larger in PACS (0.65) and PAC (0.67) (P = 0.003). To conclude, PACG and POAG individuals have narrower retinal arteries and veins.
青光眼是全球第二大致盲原因。为研究中国成年人闭角与视网膜血管直径之间的关系，我们开展了邯郸眼病研究（HES），这是一项基于人群的大型横断面研究，纳入了永年县13个随机选取村庄中年龄大于30岁的6830名参与者。在调整年龄、性别、等效球镜度（SE）、糖尿病和高血压因素后，原发性开角型青光眼（POAG）和原发性闭角型青光眼（PACG）患者的平均视网膜中央动脉等效直径（CRAE，μm）分别为127.1±7.0和145.6±4.4；比正常对照（156.1±0.4）、原发性闭角型可疑青光眼（PACS）（156.3±1.1）或原发性房角关闭（PAC）（156.0±3.4）患者更窄（P = 0.001）。POAG和PACG患者的平均视网膜中央静脉等效直径（CRVE，μm）分别为229.0±5.9和215.8±9.5；比正常对照（238.3±0.5）、PACS（241.2±1.4）或PAC（242.2±4.6）患者更窄（P = 0.001）。PACG和POAG患者的平均CRAE或CRVE无显著差异。与正常对照（0.66）相比，POAG（0.64）和PACG（0.59）患者的平均动静脉比（AVR）更小，而PACS（0.65）和PAC（0.67）患者的平均动静脉比更大（P = 0.003）。总之，PACG和POAG患者的视网膜动静脉更窄。
